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Gene Review

H2-Pb  -  histocompatibility 2, P region beta locus

Mus musculus

Synonyms: A beta3, Gm9566, H-2Ab, H-2I, H-2Pb, ...
 
 
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Disease relevance of H2-Pb

  • From the molecular characterization of the two hotspots located in the Eb gene and the Pb-Ob interval, it appeared that there are several common molecular elements, the consensus of the middle repetitive MT-family, TCTG or CCTG tetramer repeats, and the solitary long terminal repeat (LTR) of mouse retrovirus [1].
  • When inoculated with P. berghei K173 (Pb) these mouse strains did not develop cerebral malaria [2].
 

High impact information on H2-Pb

  • A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex [3].
  • In addition, B cells from H2-Ead-transgenic mice (which co-express H2-Ab and H2-Ed/b molecules) show an altered pattern of presentation of H2-Ab-restricted epitopes [4].
  • The proliferative T cell response from hyperimmunized mice was reduced but still detectable in the presence of an H-2Ab allele [5].
  • The H-2Ab allele exerts a dominant down-regulatory effect on the anti-allo-HPPD (4-hydroxyphenylpyruvate dioxygenase) antibody response, through a hitherto unknown mechanism [5].
  • A total of 12 crossover points were found to be confined to a 15-kb DNA segment of the Pb pseudogene [6].
 

Biological context of H2-Pb

  • Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa [7].
  • The Pb hotspot has several consensus motifs, an octamer transcription factor-binding sequence, the B-motif-like transcription factor-binding sequence, and tandem repeats of tetramer sequence-all of which are shared by the other three hotspots [6].
  • In particular, the wm7 haplotype derived from Japanese wild mouse indicated an approximately 2% recombination frequency within a 1.2 kb fragment of DNA in the interval between the Pb and Ob genes [1].
  • Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites [8].
 

Anatomical context of H2-Pb

  • We have addressed these questions with antigen-presenting cells (APC) from H2-M mutant mice that predominantly express a single MHC class II-peptide complex, H2-Ab bound by a peptide (CLIP) derived from the class II-associated invariant chain [9].
  • The effect of cycloheximide, chloramphenicol, ethidium bromide (EB), aurin tricarboxylic acid (ATA), and actinomycin D on the production of interferon (IFN) in human embryo fibroblasts (HAT) and L929 cells, stimulated with RNA from Piptoporus betulinus (Pb-RNA) was studied [10].
 

Other interactions of H2-Pb

  • Twenty-three breakpoints were confined within 5.4 kb in the Lmp-2 hotspot, and six breakpoints from the cas4 cross were located in the Pb hotspot, which we have now confined to a 15 kb segment [11].
  • The mutated gene has been genetically closely linked to the H-2K locus in the mouse MHC region, flanked by markers H-2Pb and D17Mit147 [12].

References

  1. Hotspots of meiotic recombination in the mouse major histocompatibility complex. Shiroishi, T., Sagai, T., Moriwaki, K. Genetica (1993) [Pubmed]
  2. Comparisons between microvascular changes in cerebral and non-cerebral malaria in mice, using the retinal whole-mount technique. Neill, A.L., Chan-Ling, T., Hunt, N.H. Parasitology (1993) [Pubmed]
  3. A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Cho, S., Attaya, M., Brown, M.G., Monaco, J.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. H2-O influence on antigen presentation in H2-E-expressing mice. Alfonso, C., Williams, G.S., Karlsson, L. Eur. J. Immunol. (2003) [Pubmed]
  5. Altered Th1/Th2 balance associated with the immunosuppressive/protective effect of the H-2Ab allele on the response to allo-4-hydroxyphenylpyruvate dioxygenase. Brunner, M., Larsen, S., Sette, A., Mitchison, A. Eur. J. Immunol. (1995) [Pubmed]
  6. Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class II region. Isobe, T., Yoshino, M., Mizuno, K., Lindahl, K.F., Koide, T., Gaudieri, S., Gojobori, T., Shiroishi, T. Genomics (2002) [Pubmed]
  7. Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa. Arimura, Y., Koda, T., Kishi, M., Kakinuma, M. Immunogenetics (1996) [Pubmed]
  8. Development and suppression of a population of late-adhering macrophages in mouse malaria. Lelchuk, R., Taverne, J., Agomo, P.U., Playfair, J.H. Parasite Immunol. (1979) [Pubmed]
  9. Peptide dependency of alloreactive CD4+ T cell responses. Mendiratta, S.K., Kovalik, J.P., Hong, S., Singh, N., Martin, W.D., Van Kaer, L. Int. Immunol. (1999) [Pubmed]
  10. The influence of inhibitors of cellular synthesis and UV irradiation on interferon induction by RNA from Piptoporus betulinus. Kandefer-Szerszeń, M., Karpińska, T., Kawecki, Z. Arch. Immunol. Ther. Exp. (Warsz.) (1982) [Pubmed]
  11. No dosage effect of recombinational hotspots in the mouse major histocompatibility complex. Yoshino, M., Sagai, T., Lindahl, K.F., Toyoda, Y., Shiroishi, T., Moriwaki, K. Immunogenetics (1994) [Pubmed]
  12. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe, K., Yuzuriha, M., Sugimoto, M., Ko, M.S., Brathwaite, M., Waeltz, P., Nagaraja, R. Mamm. Genome (2004) [Pubmed]
 
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