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Gene Review

Ciita  -  class II transactivator

Mus musculus

Synonyms: C2ta, CIITA, EG669998, Gm9475, MHC class II transactivator, ...
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Disease relevance of Ciita


High impact information on Ciita


Chemical compound and disease context of Ciita


Biological context of Ciita


Anatomical context of Ciita

  • In contrast, in the RAG cell line, C2ta transcripts were expressed at normal levels, from the proper initiation site [9].
  • These data evidence a new type of defect in a MHC class II-defective tumor cell line, as we show here that the alteration in the RAG cells occurs downstream of C2ta transcription [9].
  • In these knockout mice, MHC class II expression is nearly eliminated, although a faint RT-PCR signal is visible in spleen, lymph node, and thymus, suggestive of the presence of CIITA-independent regulation of MHC class II expression [14].
  • These results show that MHC-II-restricted Ag presentation, and its indirect influences on T cells, remains the only pathway under direct control by CIITA in vivo [15].
  • It has recently been suggested that CIITA also regulates numerous other genes having diverse functions within and outside the immune system [15].

Associations of Ciita with chemical compounds


Physical interactions of Ciita

  • An N-terminal 36 amino acids of CIITA mediates suppression of the collagen alpha(2)(I) promoter via binding to CREB-binding protein (CBP) [19].
  • Hyper-phosphorylated CIITA interacts with co-activator p300, RFX5 and CIITA itself, which in turn results in induction of MHC class II promoter activity [20].

Regulatory relationships of Ciita


Other interactions of Ciita


Analytical, diagnostic and therapeutic context of Ciita


  1. Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion. Pai, R.K., Convery, M., Hamilton, T.A., Boom, W.H., Harding, C.V. J. Immunol. (2003) [Pubmed]
  2. DNA alkylating agents alleviate silencing of class II transactivator gene expression in L1210 lymphoma cells. Murphy, S.P., Holtz, R., Lewandowski, N., Tomasi, T.B., Fuji, H. J. Immunol. (2002) [Pubmed]
  3. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. Stüve, O., Youssef, S., Slavin, A.J., King, C.L., Patarroyo, J.C., Hirschberg, D.L., Brickey, W.J., Soos, J.M., Piskurich, J.F., Chapman, H.A., Zamvil, S.S. J. Immunol. (2002) [Pubmed]
  4. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guérin involves class II transactivator and depends on the Nramp1 gene. Wojciechowski, W., DeSanctis, J., Skamene, E., Radzioch, D. J. Immunol. (1999) [Pubmed]
  5. Generating MHC Class II+/Ii- phenotype after adenoviral delivery of both an expressible gene for MHC Class II inducer and an antisense Ii-RNA construct in tumor cells. Hillman, G.G., Kallinteris, N.L., Li, J., Wang, Y., Lu, X., Li, Y., Wu, S., Wright, J.L., Slos, P., Gulfo, J.V., Humphreys, R.E., Xu, M. Gene Ther. (2003) [Pubmed]
  6. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
  7. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Gourley, T., Roys, S., Lukacs, N.W., Kunkel, S.L., Flavell, R.A., Chang, C.H. Immunity (1999) [Pubmed]
  8. Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice. Kim, T.W., Park, H.J., Choi, E.Y., Jung, K.C. J. Korean Med. Sci. (2006) [Pubmed]
  9. MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator. Naves, R., Lennon, A.M., Barbieri, G., Reyes, L., Puga, G., Salas, L., Deffrennes, V., Rosemblatt, M., Fellous, M., Charron, D., Alcaïde-Loridan, C., Bono, M.R. Int. Immunol. (2002) [Pubmed]
  10. Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation. Acosta Rodriguez, E.V., Zuñiga, E., Montes, C.L., Gruppi, A. J. Leukoc. Biol. (2003) [Pubmed]
  11. Class II transactivator (CIITA) promoter methylation does not correlate with silencing of CIITA transcription in trophoblasts. Holtz, R., Choi, J.C., Petroff, M.G., Piskurich, J.F., Murphy, S.P. Biol. Reprod. (2003) [Pubmed]
  12. Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. Chou, S.D., Khan, A.N., Magner, W.J., Tomasi, T.B. Int. Immunol. (2005) [Pubmed]
  13. Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins. Broxmeyer, H.E., Cooper, S., Hangoc, G., Chang, C.H. Exp. Hematol. (2006) [Pubmed]
  14. Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. Itoh-Lindstrom, Y., Piskurich, J.F., Felix, N.J., Wang, Y., Brickey, W.J., Platt, J.L., Koller, B.H., Ting, J.P. J. Immunol. (1999) [Pubmed]
  15. Revisiting the specificity of the MHC class II transactivator CIITA in vivo. Otten, L.A., Leibundgut-Landmann, S., Huarte, J., Kos-Braun, I.C., Lavanchy, C., Barras, E., Borisch, B., Steimle, V., Acha-Orbea, H., Reith, W. Eur. J. Immunol. (2006) [Pubmed]
  16. A CIITA-independent pathway that promotes expression of endogenous rather than exogenous peptides in immune-privileged sites. Arancibia-Cárcamo, C.V., Osawa, H., Arnett, H.A., Háskova, Z., George, A.J., Ono, S.J., Ting, J.P., Streilein, J.W. Eur. J. Immunol. (2004) [Pubmed]
  17. In vivo class II transactivator expression in mice is induced by a non-interferon-gamma mechanism in response to local injury. Sims, T.N., Goes, N.B., Ramassar, V., Urmson, J., Halloran, P.F. Transplantation (1997) [Pubmed]
  18. Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Xu, Y., McDonald, J., Perloff, E., Buttic??, G., Schreiber, B.M., Smith, B.D. Mol. Immunol. (2007) [Pubmed]
  19. A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters. Zhu, X.S., Ting, J.P. Mol. Cell. Biol. (2001) [Pubmed]
  20. Phosphorylation of class II transactivator regulates its interaction ability and transactivation function. Sisk, T.J., Nickerson, K., Kwok, R.P., Chang, C.H. Int. Immunol. (2003) [Pubmed]
  21. Enhanced production of IL-10 by dendritic cells deficient in CIITA. Yee, C.S., Yao, Y., Xu, Q., McCarthy, B., Sun-Lin, D., Tone, M., Waldmann, H., Chang, C.H. J. Immunol. (2005) [Pubmed]
  22. ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages. Yao, Y., Xu, Q., Kwon, M.J., Matta, R., Liu, Y., Hong, S.C., Chang, C.H. J. Immunol. (2006) [Pubmed]
  23. Cutting edge: the class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression. Gourley, T.S., Chang, C.H. J. Immunol. (2001) [Pubmed]
  24. Altered Th1 cell differentiation programming by CIITA deficiency. Patel, D.R., Kaplan, M.H., Chang, C.H. J. Immunol. (2004) [Pubmed]
  25. Prolonged survival of class II transactivator-deficient cardiac allografts. June Brickey, W., Felix, N.J., Griffiths, R., Zhang, J., Wang, B., Piskurich, J.F., Itoh-Lindstrom, Y., Coffman, T.M., Ting, J.P. Transplantation (2002) [Pubmed]
  26. Cathepsin E: a novel target for regulation by class II transactivator. Yee, C.S., Yao, Y., Li, P., Klemsz, M.J., Blum, J.S., Chang, C.H. J. Immunol. (2004) [Pubmed]
  27. Differential usage of class II transactivator promoters PI and PIV during inflammation and injury in kidney. Takeuchi, O., Sims, T.N., Takei, Y., Ramassar, V., Famulski, K.S., Halloran, P.F. J. Am. Soc. Nephrol. (2003) [Pubmed]
  28. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Young, H.Y., Zucker, P., Flavell, R.A., Jevnikar, A.M., Singh, B. Transplantation (2004) [Pubmed]
  29. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Chang, C.H., Guerder, S., Hong, S.C., van Ewijk, W., Flavell, R.A. Immunity (1996) [Pubmed]
  30. Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Cenci, S., Toraldo, G., Weitzmann, M.N., Roggia, C., Gao, Y., Qian, W.P., Sierra, O., Pacifici, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  31. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. Mora, C., Wong, F.S., Chang, C.H., Flavell, R.A. J. Immunol. (1999) [Pubmed]
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