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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AIFM3  -  apoptosis-inducing factor, mitochondrion...

Homo sapiens

Synonyms: AIFL, Apoptosis-inducing factor 3, Apoptosis-inducing factor-like protein, FLJ30473
 
 
 
 
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High impact information on AIFM3

  • Furthermore, the pan-caspase inhibitor Z-VAD-fmk inhibited AIFL induced apoptosis [1].
  • The mitochondrial membrane potential of cells transfected with AIFL was significantly more depolarized than that of the control [1].
  • Subcellular fractionation and immunofluorescence staining studies revealed that AIFL is predominantly localized to the mitochondria [1].
  • Human AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox) [1].
  • Reverse transcriptase-PCR analysis showed the expression of AIFL mRNA in all tissues tested, i.e. brain, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, placenta, small intestine, and testis [1].
 

Analytical, diagnostic and therapeutic context of AIFM3

References

  1. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. Xie, Q., Lin, T., Zhang, Y., Zheng, J., Bonanno, J.A. J. Biol. Chem. (2005) [Pubmed]
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