Disease relevance of CYLC2

• We report the complete coding sequence of a cDNA, designated CYL2, derived from a murine erythroleukemia cell library [1].

High impact information on CYLC2

• Transcripts of murine erythroleukemia cell CYL2 undergo alternative polyadenylylation like that of human cyclin D1 [1].
• A major 6.5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases [1].
• The present findings suggest that CYL2 plays a role in the G1 to S phase progression [1].
• The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II [2].
• A single 6.0-kb CYL2 mRNA is produced in both avian B- and T-cells, as expected [3].

Biological context of CYLC2

• Taken together, the results suggest that cylicin II, a protein of the sperm perinuclear cytoskeleton, is a novel actin-binding protein, which probably plays a role in the actin-related events that occur during spermiogenesis and the early events of fertilization [4].

Anatomical context of CYLC2

• Immunocytochemical studies showed the presence of porcine cylicin II in the acrosomal region of round spermatids and in the postacrosomal region of late spermatids and spermatozoa, in agreement with the previously described localization of cylicins [4].

References