The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sperm Head

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sperm Head


High impact information on Sperm Head

  • The mutagenic and clastogenic (chromosome breaking) effects of the flame retardant Tris(2,3-dibromopropyl) phosphate (Tris-BP) were investigated in two mammalian in vivo assays, the bone marrow micronucleus test and the abnormal sperm head assay [6].
  • In the micronucleus test, Tris-BP was a weak clastogen, whereas in the abnormal sperm head assay, Tris-BP was observed to be strongly mutagenic [6].
  • In some patients with severely amorphous sperm heads, protein 4.1 had an abnormal sub-cellular localisation (tail instead of head) and appeared as high-molecular-weight isoforms, especially a 135 kDa species instead of the 82 kDa isoform seen in fertile sperm [7].
  • Immunodepletion of gamma-tubulin and associated molecules from the egg extract before sperm head incubation prevents the change in microtubule-organizing activity of the sperm heads [8].
  • The cytoskeletal calyx structure surrounding part of the nucleus of the mammalian sperm head contains two major kinds of basic proteins, i.e., the approximately 60-kD calicin and a group of very basic (IEP > pH 10) polypeptides ranging in size from approximately 58 to approximately 100 kD ("multiple band proteins," MBPs) [9].

Chemical compound and disease context of Sperm Head


Biological context of Sperm Head


Anatomical context of Sperm Head


Associations of Sperm Head with chemical compounds

  • This activity was labile to freezing and stimulated by 0.04% Triton X-100, and thus differed from that of sperm heads [22].
  • Treatment of caput or cauda epididymal rat sperm with a low concentration (0.05%) of the cationic detergent cetyltrimethylammonium bromide and 30 mM 2-mercaptoethanol solubilized most of the sperm structures except for the sperm head and the outer dense fiber-connecting piece complex [23].
  • The elevation of cyclic AMP concentrations in flagella-less sea urchin sperm heads [12].
  • A model is proposed in which phospholipid scrambling induces the formation of an apical membrane raft in the sperm head surface that enables albumin mediated efflux of cholesterol [24].
  • Addition of albumin caused cholesterol efflux, but only in bicarbonate-responding cells that exhibited virtually no filipin labeling in the sperm head area [24].

Gene context of Sperm Head


Analytical, diagnostic and therapeutic context of Sperm Head


  1. Modified testicular expression of stress-associated "readthrough" acetylcholinesterase predicts male infertility. Mor, I., Grisaru, D., Titelbaum, L., Evron, T., Richler, C., Wahrman, J., Sternfeld, M., Yogev, L., Meiri, N., Seidman, S., Soreq, H. FASEB J. (2001) [Pubmed]
  2. Effects of hyperthermia and radiation on mouse testis stem cells. Reid, B.O., Mason, K.A., Withers, H.R., West, J. Cancer Res. (1981) [Pubmed]
  3. Relative efficacy of short-term tests in detecting genotoxic effects of cadmium chloride in mice in vivo. Mukherjee, A., Giri, A.K., Sharma, A., Talukder, G. Mutat. Res. (1988) [Pubmed]
  4. Teratozoospermia in mice lacking the transition protein 2 (Tnp2). Adham, I.M., Nayernia, K., Burkhardt-Göttges, E., Topaloglu O, n.u.l.l., Dixkens, C., Holstein, A.F., Engel, W. Mol. Hum. Reprod. (2001) [Pubmed]
  5. Protection by gonadal steroid hormones against procarbazine-induced damage to spermatogenic function in LBNF1 hybrid rats. Parchuri, N., Wilson, G., Meistrich, M.L. J. Androl. (1993) [Pubmed]
  6. Mutagenicity of Tris(2,3-dibromopropyl) phosphate in mammalian gonad and bone marrow tissue. Salamone, M.F., Katz, M. J. Natl. Cancer Inst. (1981) [Pubmed]
  7. Abnormal expression of protein 4.1 in spermatozoa of infertile men with teratospermia. Rousseaux-Prévost, R., Lesur, P., Collier, F., Rigot, J.M., Dalla Venezia, N., Pol, P.S., Delaunay, J., Gauthier, A., Rousseaux, J. Lancet (1994) [Pubmed]
  8. Centrosome assembly in vitro: role of gamma-tubulin recruitment in Xenopus sperm aster formation. Félix, M.A., Antony, C., Wright, M., Maro, B. J. Cell Biol. (1994) [Pubmed]
  9. Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton. Hess, H., Heid, H., Franke, W.W. J. Cell Biol. (1993) [Pubmed]
  10. Vitamin C mediated protection on cisplatin induced mutagenicity in mice. Giri, A., Khynriam, D., Prasad, S.B. Mutat. Res. (1998) [Pubmed]
  11. Comparison of the clastogenic effects of antimony trioxide on mice in vivo following acute and chronic exposure. Gurnani, N., Sharma, A., Talukder, G. Biometals (1992) [Pubmed]
  12. The elevation of cyclic AMP concentrations in flagella-less sea urchin sperm heads. Garbers, D.L. J. Biol. Chem. (1981) [Pubmed]
  13. Spatial organization of repetitive DNA sequences in the bovine sperm nucleus. Powell, D., Cran, D.G., Jennings, C., Jones, R. J. Cell. Sci. (1990) [Pubmed]
  14. Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa. Glassner, M., Jones, J., Kligman, I., Woolkalis, M.J., Gerton, G.L., Kopf, G.S. Dev. Biol. (1991) [Pubmed]
  15. Human sperm sex hormone-binding globulin isoform: characterization and measurement by time-resolved fluorescence immunoassay. Selva, D.M., Bassas, L., Munell, F., Mata, A., Tekpetey, F., Lewis, J.G., Hammond, G.L. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  16. Tyrosine phosphorylation, thiol status, and protein tyrosine phosphatase in rat epididymal spermatozoa. Seligman, J., Zipser, Y., Kosower, N.S. Biol. Reprod. (2004) [Pubmed]
  17. Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface. Huarte, J., Belin, D., Bosco, D., Sappino, A.P., Vassalli, J.D. J. Cell Biol. (1987) [Pubmed]
  18. Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. Gao, Z., Garbers, D.L. J. Biol. Chem. (1998) [Pubmed]
  19. Tissue-specific expression and subcellular localisation of mammalian delta-tubulin. Smrzka, O.W., Delgehyr, N., Bornens, M. Curr. Biol. (2000) [Pubmed]
  20. Enzyme termini of a phosphocreatine shuttle. Purification and characterization of two creatine kinase isozymes from sea urchin sperm. Tombes, R.M., Shapiro, B.M. J. Biol. Chem. (1987) [Pubmed]
  21. Activation of human complement by IgG antisperm antibody and the demonstration of C3 and C5b-9-mediated immune injury to human sperm. D'Cruz, O.J., Haas, G.G., Wang, B.L., DeBault, L.E. J. Immunol. (1991) [Pubmed]
  22. Ribonuclease-sensitive DNA-synthesizing complex in human sperm heads and seminal fluid. Witkin, S.S., Korngold, G.C., Bendich, A. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  23. Polypeptide composition of rat sperm outer dense fibers. A simple procedure to isolate the fibrillar complex. Vera, J.C., Brito, M., Zuvic, T., Burzio, L.O. J. Biol. Chem. (1984) [Pubmed]
  24. Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane. Flesch, F.M., Brouwers, J.F., Nievelstein, P.F., Verkleij, A.J., van Golde, L.M., Colenbrander, B., Gadella, B.M. J. Cell. Sci. (2001) [Pubmed]
  25. Patterns of importin-alpha expression during Drosophila spermatogenesis. Giarrè, M., Török, I., Schmitt, R., Gorjánácz, M., Kiss, I., Mechler, B.M. J. Struct. Biol. (2002) [Pubmed]
  26. Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells. Tanaka, H., Iguchi, N., Egydio de Carvalho, C., Tadokoro, Y., Yomogida, K., Nishimune, Y. Biol. Reprod. (2003) [Pubmed]
  27. Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. Lefièvre, L., de Lamirande, E., Gagnon, C. Biol. Reprod. (2002) [Pubmed]
  28. Characterization of two glycosylated boar spermadhesins. Calvete, J.J., Solís, D., Sanz, L., Díaz-Mauriño, T., Schäfer, W., Mann, K., Töpfer-Petersen, E. Eur. J. Biochem. (1993) [Pubmed]
  29. Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant. Escalier, D., Bai, X.Y., Silvius, D., Xu, P.X., Xu, X. Mol. Reprod. Dev. (2003) [Pubmed]
  30. Mammalian phospholipase Czeta induces oocyte activation from the sperm perinuclear matrix. Fujimoto, S., Yoshida, N., Fukui, T., Amanai, M., Isobe, T., Itagaki, C., Izumi, T., Perry, A.C. Dev. Biol. (2004) [Pubmed]
  31. Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa. Lewis, B., Aitken, R.J. Biol. Reprod. (2001) [Pubmed]
  32. In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. II. Unscheduled DNA synthesis and sperm abnormality after treatment of spermatids. Alavantić, D., Sunjevarić, I., Cerović, G., Bozin, D., Pecevski, J. Mutat. Res. (1988) [Pubmed]
  33. Sperm nuclear histone to protamine ratio in fertile and infertile men: evidence of heterogeneous subpopulations of spermatozoa in the ejaculate. Zhang, X., Gabriel, M.S., Zini, A. J. Androl. (2006) [Pubmed]
WikiGenes - Universities