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Gene Review

ADAM3A  -  ADAM metallopeptidase domain 3A (pseudogene)

Homo sapiens

Synonyms: ADAM3, CYRN1, tMDCI
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High impact information on ADAM3A

  • However, the characterization of CYRN2 transcripts from testicular RNA of CYRN1-deficient men demonstrated many termination codons in the synthesized cyritestin cDNA [1].
  • Amino acid sequence comparisons between cyritestin and other members of the metalloprotease-disintegrin family of proteins suggested that human and mouse cyritestin and monkey tMDCI are homologous molecules [2].
  • A photoreactive retinoid denoted as ADAM-3, which was designed as the result of comparison of two fluorescent retinoids (DAM-3 and DAM-15), was synthesized and used for photoaffinity labeling of recombinant protein MBP-RAR alpha/E [3].

Biological context of ADAM3A


Anatomical context of ADAM3A


  1. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. Grzmil, P., Kim, Y., Shamsadin, R., Neesen, J., Adham, I.M., Heinlein, U.A., Schwarzer, U.J., Engel, W. Biochem. J. (2001) [Pubmed]
  2. Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction. Adham, I.M., Kim, Y., Shamsadin, R., Heinlein, U.A., Von Beust, G., Mattei, M.G., Engel, W. DNA Cell Biol. (1998) [Pubmed]
  3. Location of two photoaffinity-labeled sites on the ligand-binding domain of retinoic acid receptor alpha. Sasaki, T., Shimazawa, R., Sawada, T., Iljima, T., Fukasawa, H., Shudo, K., Hashimoto, Y., Iwasaki, S. Biol. Pharm. Bull. (1996) [Pubmed]
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