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Gene Review:

Il11ra2 - interleukin 11 receptor, alpha chain 2

Mus musculus

Synonyms: ENSMUSG00000066201, Etl-2, Etl2, IL-11 receptor subunit alpha-2, IL-11 receptor subunit beta, ...

Bilinski, P. et al.

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High impact information on Il11ra2

IL-11R beta is co-expressed with IL-11R alpha, albeit at lower levels, in embryos and in various adult tissues [1].
IL-11R beta expressed in vitro binds IL-11 with high affinity, suggesting that the mouse genome contains a second functional IL-11R [1].
IL-11R beta transcripts are abundant in testis, and, in contrast with IL-11R alpha, absent from skeletal muscle [1].

Biological context of Il11ra2

Here we show that the mouse genome contains a second gene encoding an IL-11-binding protein, referred to as IL-11R beta [1].

References

Two differentially expressed interleukin-11 receptor genes in the mouse genome. Bilinski, P., Hall, M.A., Neuhaus, H., Gissel, C., Heath, J.K., Gossler, A. Biochem. J. (1996) [Pubmed]

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