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Gene Review

IL11RA  -  interleukin 11 receptor, alpha

Homo sapiens

Synonyms: IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, Interleukin-11 receptor subunit alpha
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Disease relevance of IL11RA


High impact information on IL11RA


Biological context of IL11RA

  • The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping [8].
  • In the presence of a baseline level of IL-11Ralpha, IL-11 may subsequently regulate placentation and decidualization for the maintenance of a NP [9].
  • This study examined the expression of IL-11, IL-11Ralpha, and signal transduction factor glycoprotein 130 in different phases of endometrium (six in proliferative phase and four in secretory phase), and the decidua and villi of normal pregnancy (NP; n = 25) and anembryonic pregnancy (AP; n = 25) in the first trimester (gestational week 7-9) [9].
  • In contrast to the multiple in vitro and in vivo effects of IL-11, mice with a targeted mutation of the IL-11Ra gene (IL-11Ra-/-) did not exhibit an overt hematological phenotype [10].
  • The present study examined immunoreactive IL-11 and IL-11Ralpha in cycling rhesus monkey endometrium, at implantation sites in cynomolgus and rhesus monkeys and in human first trimester decidua and defined distinct spatial and temporal patterns [11].

Anatomical context of IL11RA


Other interactions of IL11RA

  • The exon-intron organization of the IL-11R gene (HGMW-approved symbol IL11RA) is consistent with the predicted structure of the different domains of the IL-11R alpha protein, confirming evolutionary conservation at the level of gene organization among the hematopoietic cytokine receptor family [8].

Analytical, diagnostic and therapeutic context of IL11RA


  1. Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Yoshizaki, A., Nakayama, T., Yamazumi, K., Yakata, Y., Taba, M., Sekine, I. Int. J. Oncol. (2006) [Pubmed]
  2. Over-expression of the functional interleukin-11 alpha receptor in the development of B-cell chronic lymphocytic leukemia. Tsimanis, A., Shvidel, L., Klepfish, A., Shtalrid, M., Kalinkovich, A., Berrebi, A. Leuk. Lymphoma (2001) [Pubmed]
  3. Recombinant human interleukin-11 synergizes with steel factor and interleukin-3 to promote directly the early stages of murine megakaryocyte development in vitro. Weich, N.S., Fitzgerald, M., Wang, A., Calvetti, J., Yetz-Aldape, J., Neben, S., Turner, K.J. Blood (2000) [Pubmed]
  4. IL-11 activates human endothelial cells to resist immune-mediated injury. Mahboubi, K., Biedermann, B.C., Carroll, J.M., Pober, J.S. J. Immunol. (2000) [Pubmed]
  5. Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130. Neddermann, P., Graziani, R., Ciliberto, G., Paonessa, G. J. Biol. Chem. (1996) [Pubmed]
  6. The Role of Interleukin-11 in Pregnancy Involves Up-Regulation of {alpha}2-Macroglobulin Gene through Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Pathway in the Decidua. Bao, L., Devi, S., Bowen-Shauver, J., Ferguson-Gottschall, S., Robb, L., Gibori, G. Mol. Endocrinol. (2006) [Pubmed]
  7. The production of interleukin-11 and decidualization are compromised in endometrial stromal cells derived from patients with infertility. Karpovich, N., Klemmt, P., Hwang, J.H., McVeigh, J.E., Heath, J.K., Barlow, D.H., Mardon, H.J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  8. The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping. Chérel, M., Sorel, M., Apiou, F., Lebeau, B., Dubois, S., Jacques, Y., Minvielle, S. Genomics (1996) [Pubmed]
  9. Defective production of interleukin-11 by decidua and chorionic villi in human anembryonic pregnancy. Chen, H.F., Lin, C.Y., Chao, K.H., Wu, M.Y., Yang, Y.S., Ho, H.N. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  10. The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor. Nandurkar, H.H., Robb, L., Begley, C.G. Stem Cells (1998) [Pubmed]
  11. IL-11 and IL-11Ralpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development. Dimitriadis, E., Robb, L., Liu, Y.X., Enders, A.C., Martin, H., Stoikos, C., Wallace, E., Salamonsen, L.A. Reprod. Biol. Endocrinol. (2003) [Pubmed]
  12. Interleukin-11 (IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor alpha chain and signal transducing gp130. Kimura, T., Sakabe, H., Minamiguchi, H., Fujiki, H., Abe, T., Kaneko, H., Yokota, S., Nakagawa, H., Fujii, H., Tamaki, H., Ogawa, H., Sugiyama, H., Sonoda, Y. Leukemia (1999) [Pubmed]
  13. Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Van Leuven, F., Stas, L., Hilliker, C., Miyake, Y., Bilinski, P., Gossler, A. Genomics (1996) [Pubmed]
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