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Il11ra1  -  interleukin 11 receptor, alpha chain 1

Mus musculus

Synonyms: AI314697, Enhancer trap locus homolog 2, Etl-2, Etl2, GP130, ...
 
 
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Psychiatry related information on Il11ra1

  • In contrast to haloperidol, olanzapine reduced the hyperactivity in the NR1-/- mice at a dose that produced minimal effects on locomotor activity in the wild type mice [1].
 

High impact information on Il11ra1

 

Biological context of Il11ra1

 

Anatomical context of Il11ra1

 

Associations of Il11ra1 with chemical compounds

  • A cytoskeleton-associated glycoprotein of 130-kilodalton molecular mass (GP 130) was purified from a nonionic detergent-insoluble fraction of 10-16-d-old chicken embryo brains [11].
  • Overall, these findings suggest that the NR1-/- mouse may provide a model for enhanced sensitivity to dopamine agonist-induced disruption of PPI [12].
  • Genetically altered mice with reductions in the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor have been proposed as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia [12].
  • The NR1-/- mice were less sensitive to the haloperidol-induced locomotor inhibition in comparison to the NR1+/+ mice [1].
  • Like haloperidol, risperidone and olanzapine increased PPI in both NR1+/+ and NR1-/- mice [1].
 

Regulatory relationships of Il11ra1

 

Other interactions of Il11ra1

  • The intron-exon boundaries were determined based on the mouse Etl2 and interleukin-11 receptor cDNAs that were recently cloned [13].
  • Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1 [14].
  • The glycoproteins most susceptible to neuraminidase were the high-molecular-weight acidic glycoproteins which showed marked charge heterogeneity: GP150/5.1-5.6, GP130/5.0-5.6; GP100/5.0-5.4 and GP100/4 [15].
 

Analytical, diagnostic and therapeutic context of Il11ra1

  • To investigate the essential actions mediated by the IL-11R alpha, we have generated mice with a null mutation of IL11Ra (IL11Ra-/-) by gene targeting [16].
  • To test this, mesencephalic cells were cultured and the number of dopaminergic neurons (tyrosine hydroxylase-immunoreactive cells [TH-IR] cells) expressing the NMDA R1 subunit (NR1) was determined using double-label immunofluorescence microscopy [17].
  • Using RT-PCR analysis with specific probes, we showed that RAW 264.7 cells and mouse bone marrow cells express mRNA of NMDAR subunits NMDA receptor 1 (NR1) and NMDA receptor 2 (NR2) A, B, and D. These subunits are expressed all along the differentiation sequence from undifferentiated precursors to mature resorbing osteoclasts [18].

References

  1. Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction. Duncan, G.E., Moy, S.S., Lieberman, J.A., Koller, B.H. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  2. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Robb, L., Li, R., Hartley, L., Nandurkar, H.H., Koentgen, F., Begley, C.G. Nat. Med. (1998) [Pubmed]
  3. The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. Romas, E., Udagawa, N., Zhou, H., Tamura, T., Saito, M., Taga, T., Hilton, D.J., Suda, T., Ng, K.W., Martin, T.J. J. Exp. Med. (1996) [Pubmed]
  4. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. Hilton, D.J., Hilton, A.A., Raicevic, A., Rakar, S., Harrison-Smith, M., Gough, N.M., Begley, C.G., Metcalf, D., Nicola, N.A., Willson, T.A. EMBO J. (1994) [Pubmed]
  5. Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues. Davidson, A.J., Freeman, S.A., Crosier, K.E., Wood, C.R., Crosier, P.S. Stem Cells (1997) [Pubmed]
  6. Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential. Neuhaus, H., Bettenhausen, B., Bilinski, P., Simon-Chazottes, D., Guénet, J.L., Gossler, A. Dev. Biol. (1994) [Pubmed]
  7. Antagonistic effects of dopaminergic signaling and ethanol on protein kinase A-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. Edwards, S., Simmons, D.L., Galindo, D.G., Doherty, J.M., Scott, A.M., Hughes, P.D., Wilcox, R.E. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  8. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. Wang, S., Lim, G., Zeng, Q., Sung, B., Yang, L., Mao, J. J. Neurosci. (2005) [Pubmed]
  9. Two differentially expressed interleukin-11 receptor genes in the mouse genome. Bilinski, P., Hall, M.A., Neuhaus, H., Gissel, C., Heath, J.K., Gossler, A. Biochem. J. (1996) [Pubmed]
  10. Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface. Ain, R., Trinh, M.L., Soares, M.J. Dev. Dyn. (2004) [Pubmed]
  11. A neuronal surface glycoprotein associated with the cytoskeleton. Ranscht, B., Moss, D.J., Thomas, C. J. Cell Biol. (1984) [Pubmed]
  12. Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Moy, S.S., Perez, A., Koller, B.H., Duncan, G.E. Brain Res. (2006) [Pubmed]
  13. Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Van Leuven, F., Stas, L., Hilliker, C., Miyake, Y., Bilinski, P., Gossler, A. Genomics (1996) [Pubmed]
  14. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Benigni, F., Fantuzzi, G., Sacco, S., Sironi, M., Pozzi, P., Dinarello, C.A., Sipe, J.D., Poli, V., Cappelletti, M., Paonessa, G., Pennica, D., Panayotatos, N., Ghezzi, P. Blood (1996) [Pubmed]
  15. Cell surface properties of high- and low-metastatic cell lines selected from a spontaneous mouse lung carcinoma. Steele, J.G., Rowlatt, C., Sandall, J.K., Franks, L.M. Int. J. Cancer (1983) [Pubmed]
  16. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Nandurkar, H.H., Robb, L., Tarlinton, D., Barnett, L., Köntgen, F., Begley, C.G. Blood (1997) [Pubmed]
  17. Relationship between NMDA receptor expression and MPP+ toxicity in cultured dopaminergic cells. Church, W.H., Hewett, S.J. J. Neurosci. Res. (2003) [Pubmed]
  18. NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis. Merle, B., Itzstein, C., Delmas, P.D., Chenu, C. J. Cell. Biochem. (2003) [Pubmed]
 
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