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Gene Review

FSIP1  -  fibrous sheath interacting protein 1

Homo sapiens

Synonyms: FLJ35989, Fibrous sheath-interacting protein 1, HSD10
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Disease relevance of FSIP1

  • The sequence of the 3020 Da peptide, called frog skin insulinotropic peptide or FSIP, was determined as AVWKDFLKNIGKAAGKAVLNSVTDMVNE, which has 79% homology with the C-terminal of the 75 amino acid dermaseptin BIV precursor [1].

Psychiatry related information on FSIP1


High impact information on FSIP1

  • We have determined the crystal structure of human ABAD/HSD10 complexed with NAD(+) and an inhibitory small molecule [2].
  • These results suggest that the human APP gene transferred to mice may induce overexpression of HSD-10 in mouse APs and in various other cellular components of mouse brains [3].
  • Our observations also revealed that HSD-10 was present in the blood vessels of both Tg2576 mice and AD brains [3].
  • Immunogold electron microscopy also indicated that HSD-10 was present in the amyloid fibers (AFs), mitochondria, nuclear heterochromatin, and nucleolus of Tg2576 mouse brains but was absent in APs of AD brains [3].

Chemical compound and disease context of FSIP1


Biological context of FSIP1

  • The conserved noncoding regions identified among mammals and between pufferfishes, the evidence of an alternative splicing variant conserved between human and dog, and the detection of positive selection across eutherian mammals, may be of importance for further research on ABAD/HSD10 function and its implication in the Alzheimer's disease [4].

Other interactions of FSIP1

  • Alternatively, the HSD-10 gene and APP gene may function independently in AD brains [3].
  • Here we use comparative genomic analyses to study the evolution of the HADH2 gene encoding ABAD/HSD10 across several eukaryotic species [4].

Analytical, diagnostic and therapeutic context of FSIP1

  • Despite these differences, the Tg2576 mouse, as shown in this study, is a proper animal model for the study of AD and also for the investigation of HSD-10 [3].


  1. Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas. Marenah, L., Shaw, C., Orr, D.F., McClean, S., Flatt, P.R., Abdel-Wahab, Y.H. Regul. Pept. (2004) [Pubmed]
  2. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics. Kissinger, C.R., Rejto, P.A., Pelletier, L.A., Thomson, J.A., Showalter, R.E., Abreo, M.A., Agree, C.S., Margosiak, S., Meng, J.J., Aust, R.M., Vanderpool, D., Li, B., Tempczyk-Russell, A., Villafranca, J.E. J. Mol. Biol. (2004) [Pubmed]
  3. Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains. Wen, G.Y., Yang, S.Y., Kaczmarski, W., He, X.Y., Pappas, K.S. Brain Res. (2002) [Pubmed]
  4. Comparative evolutionary genomics of the HADH2 gene encoding Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10). Marques, A.T., Antunes, A., Fernandes, P.A., Ramos, M.J. BMC Genomics (2006) [Pubmed]
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