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Chemical Compound Review

AC1L9890     (17S)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...

Synonyms: C03051, 17beta-Hydroxysteroid
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Disease relevance of C03051


Psychiatry related information on C03051


High impact information on C03051


Chemical compound and disease context of C03051


Biological context of C03051


Anatomical context of C03051

  • All other mRNA species measured showed significantly reduced expression in older animals, and three of these mRNA species (17beta-hydroxysteroid dehydrogenase type III, prostaglandin D (PGD)-synthetase and 3betaHSD type VI), which are only expressed in the adult population of Leydig cells, were barely detectable in the adult AR-null mouse [21].
  • Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2 [22].
  • The properties of delta-5-3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in the human testis were examined using cell-free homogenates with added cofactors [23].
  • Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle [24].
  • 0. It appears likely that in a cell-free system human testicular 17beta-hydroxysteroid oxidoreductase not solubilized and still attached to membrane is activated by the product of the reaction catalyzed by the enzyme [25].

Associations of C03051 with other chemical compounds


Gene context of C03051


Analytical, diagnostic and therapeutic context of C03051


  1. Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+. Sawicki, M.W., Erman, M., Puranen, T., Vihko, P., Ghosh, D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. 17Beta-hydroxysteroid dehydrogenases in human bone cells. Dong, Y., Qiu, Q.Q., Debear, J., Lathrop, W.F., Bertolini, D.R., Tamburini, P.P. J. Bone Miner. Res. (1998) [Pubmed]
  3. Divergent effects of retinoic acids on the expression of ERalpha and 17beta-hydroxysteroid dehydrogenase type 2 in endometrial carcinoma cells (RL 95-2). Li, X.H., Li, H., Xiao, Z.J., Piao, Y.S. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  4. Increased expression of type I 17beta-hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma. Kasai, T., Shozu, M., Murakami, K., Segawa, T., Shinohara, K., Nomura, K., Inoue, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  5. 17Beta-hydroxysteroid dehydrogenase-3 deficiency: diagnosis, phenotypic variability, population genetics, and worldwide distribution of ancient and de novo mutations. Boehmer, A.L., Brinkmann, A.O., Sandkuijl, L.A., Halley, D.J., Niermeijer, M.F., Andersson, S., de Jong, F.H., Kayserili, H., de Vroede, M.A., Otten, B.J., Rouwé, C.W., Mendonça, B.B., Rodrigues, C., Bode, H.H., de Ruiter, P.E., Delemarre-van de Waal, H.A., Drop, S.L. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  6. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics. Kissinger, C.R., Rejto, P.A., Pelletier, L.A., Thomson, J.A., Showalter, R.E., Abreo, M.A., Agree, C.S., Margosiak, S., Meng, J.J., Aust, R.M., Vanderpool, D., Li, B., Tempczyk-Russell, A., Villafranca, J.E. J. Mol. Biol. (2004) [Pubmed]
  7. Gender identity in XY intersexuality. Sobel, V., Imperato-McGinley, J. Child and adolescent psychiatric clinics of North America. (2004) [Pubmed]
  8. Unusual evolution of 11beta- and 17beta-hydroxysteroid and retinol dehydrogenases. Baker, M.E. Bioessays (1996) [Pubmed]
  9. Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation. Shi, R., Lin, S.X. J. Biol. Chem. (2004) [Pubmed]
  10. Critical residues for structure and catalysis in short-chain dehydrogenases/reductases. Filling, C., Berndt, K.D., Benach, J., Knapp, S., Prozorovski, T., Nordling, E., Ladenstein, R., Jörnvall, H., Oppermann, U. J. Biol. Chem. (2002) [Pubmed]
  11. Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibians. Mensah-Nyagan, A.G., Beaujean, D., Luu-The, V., Pelletier, G., Vaudry, H. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  12. Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase. He, X.Y., Merz, G., Mehta, P., Schulz, H., Yang, S.Y. J. Biol. Chem. (1999) [Pubmed]
  13. The influence of oestradiol on the metabolism of androgens by human prostatic tissue. Bard, D.R., Lasnitzki, I. J. Endocrinol. (1977) [Pubmed]
  14. Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells. Chetrite, G., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  15. Effect of nomegestrol acetate on estrone-sulfatase and 17beta-hydroxysteroid dehydrogenase activities in human breast cancer cells. Chetrite, G., Paris, J., Botella, J., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  16. Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines. Chetrite, G.S., Ebert, C., Wright, F., Philippe, J.C., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  17. 17Beta-hydroxysteroid dehydrogenase type 1 in normal breast tissue during the menstrual cycle and hormonal contraception. Söderqvist, G., Poutanen, M., Wickman, M., von Schoultz, B., Skoog, L., Vihko, R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  18. Tissue- and site-specific gene expression of type 2 17beta-hydroxysteroid dehydrogenase: in situ hybridization and specificenzymatic activity studies in human placental endothelial cells of the arterial system. Bonenfant, M., Blomquist, C.H., Provost, P.R., Drolet, R., D'Ascoli, P., Tremblay, Y. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  19. 17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development. Takeyama, J., Sasano, H., Suzuki, T., Iinuma, K., Nagura, H., Andersson, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  20. Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid dehydrogenase 3 gene (HSD17B3). Moghrabi, N., Hughes, I.A., Dunaif, A., Andersson, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  21. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. O'Shaughnessy, P.J., Johnston, H., Willerton, L., Baker, P.J. J. Cell. Sci. (2002) [Pubmed]
  22. Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2. Yang, S., Fang, Z., Gurates, B., Tamura, M., Miller, J., Ferrer, K., Bulun, S.E. Mol. Endocrinol. (2001) [Pubmed]
  23. Studies of the human testis. V. Properties of delta-5-3beta and 17beta-hydroxysteroid dehydrogenases in the biosynthesis of testosterone from dehydroepiandrosterone]. Oshima, H., Fan, D.F., Troen, P. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  24. Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle. Mustonen, M.V., Isomaa, V.V., Vaskivuo, T., Tapanainen, J., Poutanen, M.H., Stenbäck, F., Vihko, R.K., Vihko, P.T. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  25. Studies of the human testis. VIII. Product activation of 17beta-hydroxysteroid oxidoreductase for testosterone. Oshima, H., Paraska, L., Yoshida, K.I., Troen, P. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  26. Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues. Qiu, W., Zhou, M., Labrie, F., Lin, S.X. Mol. Endocrinol. (2004) [Pubmed]
  27. Progesterone receptor isoform A but not B is expressed in endometriosis. Attia, G.R., Zeitoun, K., Edwards, D., Johns, A., Carr, B.R., Bulun, S.E. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  28. Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium. Kitawaki, J., Koshiba, H., Ishihara, H., Kusuki, I., Tsukamoto, K., Honjo, H. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  29. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Marijanovic, Z., Laubner, D., Moller, G., Gege, C., Husen, B., Adamski, J., Breitling, R. Mol. Endocrinol. (2003) [Pubmed]
  30. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Rizner, T.L., Lin, H.K., Peehl, D.M., Steckelbroeck, S., Bauman, D.R., Penning, T.M. Endocrinology (2003) [Pubmed]
  31. The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad. Britt, K.L., Stanton, P.G., Misso, M., Simpson, E.R., Findlay, J.K. Endocrinology (2004) [Pubmed]
  32. Cyclooxygenase-2 and prostaglandin F2 alpha in Syrian hamster Leydig cells: Inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production. Frungieri, M.B., Gonzalez-Calvar, S.I., Parborell, F., Albrecht, M., Mayerhofer, A., Calandra, R.S. Endocrinology (2006) [Pubmed]
  33. Aromatase and intracrinology of estrogen in hormone-dependent tumors. Harada, N. Oncology (1999) [Pubmed]
  34. The rat 17beta-hydroxysteroid dehydrogenase type III: molecular cloning and gonadotropin regulation. Tsai-Morris, C.H., Khanum, A., Tang, P.Z., Dufau, M.L. Endocrinology (1999) [Pubmed]
  35. Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. El-Alfy, M., Luu-The, V., Huang, X.F., Berger, L., Labrie, F., Pelletier, G. Endocrinology (1999) [Pubmed]
  36. Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis. Qiu, W., Zhu, D.W., Azzi, A., Campbell, R.L., Qi, H., Poirier, D., Lin, S.X. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  37. In silico Northern blot, an automated method to determine expression patterns from EST databases, reveals tissue specificity of murine 17beta-hydroxysteroid dehydrogenase type 11. Keller, B., Grote, K., Adamski, J. Mol. Cell. Endocrinol. (2006) [Pubmed]
  38. Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells. Nagayoshi, Y., Ohba, T., Yamamoto, H., Miyahara, Y., Tashiro, H., Katabuchi, H., Okamura, H. Mol. Hum. Reprod. (2005) [Pubmed]
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