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Chemical Compound Review

AC1L9890     (17S)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...

Synonyms: C03051, 17beta-Hydroxysteroid
 
 
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Disease relevance of C03051

 

Psychiatry related information on C03051

 

High impact information on C03051

 

Chemical compound and disease context of C03051

 

Biological context of C03051

 

Anatomical context of C03051

  • All other mRNA species measured showed significantly reduced expression in older animals, and three of these mRNA species (17beta-hydroxysteroid dehydrogenase type III, prostaglandin D (PGD)-synthetase and 3betaHSD type VI), which are only expressed in the adult population of Leydig cells, were barely detectable in the adult AR-null mouse [21].
  • Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2 [22].
  • The properties of delta-5-3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in the human testis were examined using cell-free homogenates with added cofactors [23].
  • Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle [24].
  • 0. It appears likely that in a cell-free system human testicular 17beta-hydroxysteroid oxidoreductase not solubilized and still attached to membrane is activated by the product of the reaction catalyzed by the enzyme [25].
 

Associations of C03051 with other chemical compounds

 

Gene context of C03051

 

Analytical, diagnostic and therapeutic context of C03051

References

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  4. Increased expression of type I 17beta-hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma. Kasai, T., Shozu, M., Murakami, K., Segawa, T., Shinohara, K., Nomura, K., Inoue, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
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  11. Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibians. Mensah-Nyagan, A.G., Beaujean, D., Luu-The, V., Pelletier, G., Vaudry, H. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  12. Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase. He, X.Y., Merz, G., Mehta, P., Schulz, H., Yang, S.Y. J. Biol. Chem. (1999) [Pubmed]
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  15. Effect of nomegestrol acetate on estrone-sulfatase and 17beta-hydroxysteroid dehydrogenase activities in human breast cancer cells. Chetrite, G., Paris, J., Botella, J., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  16. Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines. Chetrite, G.S., Ebert, C., Wright, F., Philippe, J.C., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  17. 17Beta-hydroxysteroid dehydrogenase type 1 in normal breast tissue during the menstrual cycle and hormonal contraception. Söderqvist, G., Poutanen, M., Wickman, M., von Schoultz, B., Skoog, L., Vihko, R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  18. Tissue- and site-specific gene expression of type 2 17beta-hydroxysteroid dehydrogenase: in situ hybridization and specificenzymatic activity studies in human placental endothelial cells of the arterial system. Bonenfant, M., Blomquist, C.H., Provost, P.R., Drolet, R., D'Ascoli, P., Tremblay, Y. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  19. 17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development. Takeyama, J., Sasano, H., Suzuki, T., Iinuma, K., Nagura, H., Andersson, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  20. Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid dehydrogenase 3 gene (HSD17B3). Moghrabi, N., Hughes, I.A., Dunaif, A., Andersson, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  21. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. O'Shaughnessy, P.J., Johnston, H., Willerton, L., Baker, P.J. J. Cell. Sci. (2002) [Pubmed]
  22. Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2. Yang, S., Fang, Z., Gurates, B., Tamura, M., Miller, J., Ferrer, K., Bulun, S.E. Mol. Endocrinol. (2001) [Pubmed]
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  24. Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle. Mustonen, M.V., Isomaa, V.V., Vaskivuo, T., Tapanainen, J., Poutanen, M.H., Stenbäck, F., Vihko, R.K., Vihko, P.T. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  25. Studies of the human testis. VIII. Product activation of 17beta-hydroxysteroid oxidoreductase for testosterone. Oshima, H., Paraska, L., Yoshida, K.I., Troen, P. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  26. Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues. Qiu, W., Zhou, M., Labrie, F., Lin, S.X. Mol. Endocrinol. (2004) [Pubmed]
  27. Progesterone receptor isoform A but not B is expressed in endometriosis. Attia, G.R., Zeitoun, K., Edwards, D., Johns, A., Carr, B.R., Bulun, S.E. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  28. Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium. Kitawaki, J., Koshiba, H., Ishihara, H., Kusuki, I., Tsukamoto, K., Honjo, H. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  29. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Marijanovic, Z., Laubner, D., Moller, G., Gege, C., Husen, B., Adamski, J., Breitling, R. Mol. Endocrinol. (2003) [Pubmed]
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  35. Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. El-Alfy, M., Luu-The, V., Huang, X.F., Berger, L., Labrie, F., Pelletier, G. Endocrinology (1999) [Pubmed]
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  37. In silico Northern blot, an automated method to determine expression patterns from EST databases, reveals tissue specificity of murine 17beta-hydroxysteroid dehydrogenase type 11. Keller, B., Grote, K., Adamski, J. Mol. Cell. Endocrinol. (2006) [Pubmed]
  38. Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells. Nagayoshi, Y., Ohba, T., Yamamoto, H., Miyahara, Y., Tashiro, H., Katabuchi, H., Okamura, H. Mol. Hum. Reprod. (2005) [Pubmed]
 
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