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Gene Review:

Ipp - IAP promoted placental gene

Mus musculus

Synonyms: Actin-binding protein IPP, D4Jhu8, IPP, Intracisternal A particle-promoted polypeptide, Mipp, ...

VanHouten, J.N. et al., Chang-Yeh, A. et al.

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High impact information on Ipp

The symbol Ipp is being used for this gene in all major mouse data bases and in the comparative section of the human genome data base [1].
Restriction fragment length polymorphism studies using inbred strains and recombinant inbred mice have further established the linkage between the MIPP gene (D4Jhu8) and several loci on distal mouse chromosome 4 [1].
A placenta-specific gene, MIPP, is transcriptionally regulated in BALB/c mice by a solo long terminal repeat (LTR) of an intracisternal A-particle (IAP), an endogenous retrotransposon [2].

Analytical, diagnostic and therapeutic context of Ipp

Despite the parallel expression of the placental gene and IAPs in the mammary tissues, RT-PCR showed that LTR sequences are absent from tumor-associated MIPP transcripts [2].

References

The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific. Chang-Yeh, A., Mold, D.E., Brilliant, M.H., Huang, R.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Frequent ectopic expression of a placenta-specific gene at high levels in BALB/c mouse mammary carcinomas. VanHouten, J.N., Natoli, F., Asch, B.B. Oncogene (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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IPP	Bos taurus
IPP	Canis lupus familiaris
ipp	Danio rerio
CG9426	Drosophila melanogaster
IPP	Gallus gallus
IPP	Homo sapiens
IPP	Macaca mulatta
IPP	Pan troglodytes
Ipp	Rattus norvegicus
ipp	Xenopus (Silurana) tropicalis

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