Gene Review:
Kif17 - kinesin family member 17
Mus musculus
Synonyms:
5930435E01Rik, AW492270, Kif17b, Kinesin-like protein KIF17, MmKIF17, ...
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High impact information on Kif17
- Kv4.2 colocalizes with Kif17 but not with other kinesin isoforms in dendrites of cortical neurons [1].
- Here we present evidence that the K+ channel Kv4.2, which is a major regulator of dendritic excitability, is transported to dendrites by the kinesin isoform Kif17 [1].
Anatomical context of Kif17
- Native Kv4.2 and Kif17 coimmunoprecipitate from brain lysate, and introduced, tagged versions of the two proteins coimmunoprecipitate from COS cell lysate, indicating that the two proteins interact, either directly or indirectly [1].
Physical interactions of Kif17
Regulatory relationships of Kif17
- We show that a dominant negative construct against Kif17 dramatically inhibits localization to dendrites of both introduced and endogenous Kv4.2, but those against other kinesins found in dendrites do not [1].
References
- A role for Kif17 in transport of Kv4.2. Chu, P.J., Rivera, J.F., Arnold, D.B. J. Biol. Chem. (2006) [Pubmed]
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