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Gene Review:

KIF17 - kinesin family member 17

Homo sapiens

Synonyms: KIAA1405, KIF17B, KIF3-related motor protein, KIF3X, KLP-2, ...

Guillaud, L. et al., Kayadjanian, N. et al., Setou, M. et al.

Kayadjanian, Lee, Piña-Crespo, Heinemann,

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High impact information on KIF17

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport [1].
The overlap between GluR5 distribution and the organization of microtubules in dendrites led us to examine whether KIF17, a microtubule motor protein expressed in distal dendrites, is involved in GluR5 localization to distal dendrites [2].
Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17 [2].
In contrast, upregulation of the expression level of NR2B, after treatment with the NMDAR antagonist D(-)-2-amino-5-phosphonopentanoic acid, simultaneously increases the expression level of KIF17 [3].
These observations concerning the downregulation or upregulation of KIF17 and NR2B reveal the probable existence of a shared regulation process between the motor and its cargo [3].

References

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Setou, M., Nakagawa, T., Seog, D.H., Hirokawa, N. Science (2000) [Pubmed]
Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Kayadjanian, N., Lee, H.S., Piña-Crespo, J., Heinemann, S.F. Mol. Cell. Neurosci. (2007) [Pubmed]
KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. Guillaud, L., Setou, M., Hirokawa, N. J. Neurosci. (2003) [Pubmed]

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AgaP_AGAP003323	Anopheles gambiae str. PEST
KIF17	Bos taurus
osm-3	Caenorhabditis elegans
KIF17	Canis lupus familiaris
kif17	Danio rerio
Kif3C	Drosophila melanogaster
KIF17	Macaca mulatta
Kif17	Mus musculus
KIF17	Pan troglodytes
Kif17	Rattus norvegicus

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