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Gene Review

osm-3  -  Protein OSM-3

Caenorhabditis elegans

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High impact information on osm-3

  • Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons [1].
  • C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein [2].
  • In the nematode Caenorhabditis elegans, mutants in osm-3 gene are known to be defective in osmotic avoidance, chemotaxis and dauer formation behaviours [2].
  • Our results are consistent with the previous EM data on osm-3 (p802) mutants that show an accumulation of dense matrix material in the amphid sheath cytoplasm and a shortened distal segment of the amphid channel cilium [2].

Biological context of osm-3


Analytical, diagnostic and therapeutic context of osm-3

  • To study the molecular basis of these pleiotropic defects we have cloned the osm-3 gene by germline transformation of osm-3 (p802) mutants through microinjection of the wild type genomic DNA [2].


  1. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. de Bono, M., Tobin, D.M., Davis, M.W., Avery, L., Bargmann, C.I. Nature (2002) [Pubmed]
  2. C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein. Shakir, M.A., Fukushige, T., Yasuda, H., Miwa, J., Siddiqui, S.S. Neuroreport (1993) [Pubmed]
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