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Gene Review:

Klra10 - killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: Ly49J, Ly49i2

Lavender, K.J. et al.

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High impact information on Klra10

Through mutagenesis, we show that the supertype-defining B-pocket of RT1-A1(c) controls its allele-specific recognition by the syngeneic rat Ly49i2 inhibitory receptor and xenogeneic mouse inhibitory Ly49G and activating Ly49W receptors [1].
In examining the specificity of mouse and rat Ly49, we noticed that MHC I ligands for mouse Ly49G and W, and the rat Ly49i2, typically share the HLA-B7 supertype, defined by a B-pocket that prefers a proline at position 2 in bound peptides [1].

References

Cross-species dependence of ly49 recognition on the supertype defining B-pocket of a class I MHC molecule. Lavender, K.J., Kane, K.P. J. Immunol. (2006) [Pubmed]

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