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Gene Review

Klra9  -  killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: LY49I1, Ly49I
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High impact information on Klra9

  • During the first days after birth, few or no splenic NK cells express Ly49A, Ly49C, Ly49G2, or Ly49I receptors [1].
  • Nevertheless, Ly49I was partly masked on transfected tumor cells, suggesting that the structure of Ly49I is compatible in principal with cis binding of MHC-I [2].
  • FVB (H2(q)) mice transgenic for the B6 strain Ly49I (Ly49I(B6)) express the inhibitory Ly49 receptor on the surface of both T and NK cells [3].
  • Only upon stimulation with suboptimal doses of anti-CD3 in the presence of anti-Ly49I is T cell proliferation inhibited [3].
  • Ly49I NK cell receptor transgene inhibition of rejection of H2b mouse bone marrow transplants [4].

Biological context of Klra9


Anatomical context of Klra9

  • To determine the function of the Ly49I gene in the rejection of BMC grafts, we transfected fertilized eggs of FVB mice with a vector containing DNA for B6 strain Ly49I (Ly49IB6) [4].

Analytical, diagnostic and therapeutic context of Klra9


  1. Acquisition of Ly49 receptor expression by developing natural killer cells. Dorfman, J.R., Raulet, D.H. J. Exp. Med. (1998) [Pubmed]
  2. Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis. Scarpellino, L., Oeschger, F., Guillaume, P., Coudert, J.D., Lévy, F., Leclercq, G., Held, W. J. Immunol. (2007) [Pubmed]
  3. B6 strain Ly49I inhibitory gene expression on T cells in FVB.Ly49IB6 transgenic mice fails to prevent normal T cell functions. Morris, M.A., Liu, J., Arora, V., George, T.C., Klem, J., Schatzle, J.D., Kumar, V., Bennett, M. J. Immunol. (2002) [Pubmed]
  4. Ly49I NK cell receptor transgene inhibition of rejection of H2b mouse bone marrow transplants. Liu, J., Morris, M.A., Nguyen, P., George, T.C., Koulich, E., Lai, W.C., Schatzle, J.D., Kumar, V., Bennett, M. J. Immunol. (2000) [Pubmed]
  5. Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family. Dimasi, N., Sawicki, M.W., Reineck, L.A., Li, Y., Natarajan, K., Margulies, D.H., Mariuzza, R.A. J. Mol. Biol. (2002) [Pubmed]
  6. Characterization of the Ly49I promoter. Gosselin, P., Makrigiannis, A.P., Nalewaik, R., Anderson, S.K. Immunogenetics (2000) [Pubmed]
  7. Definition of additional functional ligands for Ly49I(B6) using FVBLy49I(B6) transgenic mice and B6 natural killer cell effectors. Morris, M.A., Koulich, E., Liu, J., Arora, V., George, T.C., Schatzle, J.D., Kumar, V., Bennett, M. Transplantation (2002) [Pubmed]
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