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Gene Review

DHX15  -  DEAH (Asp-Glu-Ala-His) box helicase 15

Homo sapiens

Synonyms: ATP-dependent RNA helicase #46, DBP1, DDX15, DEAH box protein 15, HRH2, ...
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High impact information on DHX15

  • Immunofluorescence data indicated that endogenous DDX15 accumulates in U snRNP containing nuclear speckles in HEp-2 cells [1].
  • RNA coprecipitation experiments indicated that DDX15 is associated with spliceosomal U small nuclear RNAs in HeLa cell extracts [1].
  • DBP1 and DBP2 both appeared to have one binding site for 25-hydroxyvitamin D3 per molecule of protein, with apparently similar association constants at 4 degrees C of 5--7 x 10(9) M-1 [2].

Analytical, diagnostic and therapeutic context of DHX15


  1. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. Fouraux, M.A., Kolkman, M.J., Van der Heijden, A., De Jong, A.S., Van Venrooij, W.J., Pruijn, G.J. RNA (2002) [Pubmed]
  2. Isolation and partial characterization of two immunologically similar vitamin D-binding proteins in rat serum. Imawari, M., Akanuma, Y., Muto, Y., Itakura, H., Kosaka, K. J. Biochem. (1980) [Pubmed]
  3. A monoclonal antibody against human vitamin-D-binding protein for the analysis of genetic variation in the group-specific component system (Gc). Hoffmann, R., Braun, A., Cleve, H. Hum. Genet. (1990) [Pubmed]
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