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Gene Review

Lad1  -  ladinin

Mus musculus

Synonyms: LADA, Lad-1, Ladinin-1, Linear IgA disease antigen homolog
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High impact information on Lad1

  • The bm12 mutant strongly stimulates the parental C57BL/6 strain in an mixed lymphocyte reaction (MLR), and the reciprocal also occurs, the degree of stimulation being similar to that obtained with K + IA differences originating in another H-2 haplotype and points to the mutation effecting the Lad-1 locus [1].
  • We have also characterized the promoter region of Lad1 and examined its tissue-specific expression [2].
  • The mouse Lad1 gene consists of 10 exons spanning approximately 13.4 kb of the mouse genome on chromosome 1, and Southern analysis suggested that Lad1 is a single-copy gene [2].
  • Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component [2].


  1. B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse. McKenzie, I.F., Morgan, G.M., Sandrin, M.S., Michaelides, M.M., Melvold, R.W., Kohn, H.I. J. Exp. Med. (1979) [Pubmed]
  2. Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component. Motoki, K., Megahed, M., LaForgia, S., Uitto, J. Genomics (1997) [Pubmed]
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