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Gene Review: 

Rnr1  -  s-rRNA

Rattus norvegicus

 
 
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High impact information on Rnr1

  • To resolve this problem, we sequenced a region (2,645 bp) of the mitochondrial genome of the guinea pig containing the complete 12S ribosomal RNA, 16S ribosomal RNA, and transfer RNA(VAL) genes for comparison with the available sciurognath and other mammalian sequences [1].
  • Northern blot analysis demonstrated that CO-III and ATPase-6 were downregulated 1.8- and 2.3-fold by 400-lux cyclic light compared with 5-lux cyclic light, respectively; however, there was no change in cytochrome c oxidase subunit I and II (CO-I and -II) or in 12S ribosomal RNA (12S rRNA), a mitochondrial housekeeping gene [2].
  • The lower islet mtDNA contents were paralleled by a decreased content of islet mtRNA (12S ribosomal RNA and cytochrome b messenger RNA) [3].

References

  1. Monophyly of the order Rodentia inferred from mitochondrial DNA sequences of the genes for 12S rRNA, 16S rRNA, and tRNA-valine. Frye, M.S., Hedges, S.B. Mol. Biol. Evol. (1995) [Pubmed]
  2. Downregulation of ATP synthase subunit-6, cytochrome c oxidase-III, and NADH dehydrogenase-3 by bright cyclic light in the rat retina. Huang, H., Li, F., Alvarez, R.A., Ash, J.D., Anderson, R.E. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes. Serradas, P., Giroix, M.H., Saulnier, C., Gangnerau, M.N., Borg, L.A., Welsh, M., Portha, B., Welsh, N. Endocrinology (1995) [Pubmed]
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