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Gene Review

mt-Co1  -  cytochrome c oxidase I, mitochondrial

Rattus norvegicus

Synonyms: COX1, Coi, Cytochrome c oxidase polypeptide I, Cytochrome c oxidase subunit 1, Mtco1, ...
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Disease relevance of mt-Co1

  • These data demonstrate that a dramatic decrease in antioxidant defense was initiated during warm renal ischemia, whereas the 8-iso-PGF(2alpha) was related only to arachidonate conversion by COX1 [1].
  • However, the concurrent inhibition of endogenous nitric oxide generation and COX1 or COX2 causes overshooting neointimal hyperplasia [2].
  • These findings demonstrate that COX-1- and COX-2-derived prostanoids contribute importantly to the development of malignant hypertension in Cyp1a1-Ren2 transgenic rats [3].
  • This study was designed to examine the effect of perinatal hypothyroidism on ontogenic change in cytochrome c oxidase subunit I (COX I) gene expression in the rat cerebellum by using quantitative in situ hybridization histochemistry (ISH) [4].

Psychiatry related information on mt-Co1


High impact information on mt-Co1


Chemical compound and disease context of mt-Co1

  • Additional rats received Pio (10 for 3 days and intravenous SC-58125 [a cyclooxygenase-2 (COX-2) inhibitor] or SC-560 (a COX-1 inhibitor) 15 min before ischemia [10].
  • Adv-COX-1/PGIS infusion selectively augmented prostacyclin levels, with reduction of other eicosanoids in ischemic cortex and a significant reduction of infarct volume, even when the rAd was administered 5 hours after ischemia [11].

Biological context of mt-Co1


Anatomical context of mt-Co1

  • The mechanism of action involves an over-expression of COX-2, but not COX-1, in dorsal and ventral horn areas of the lumbar spinal cord [17].
  • In conclusion, the expression of iNOS in the small intestine following administration of NSAIDs results from COX-1 inhibition and is functionally associated with intestinal hypermotility and bacterial invasion [18].
  • COX1 was increased by TGFbeta1, but only in astrocytes [19].
  • To determine cellular expression, frozen sections of rat tibial growth plate and primary chondrocyte cultures were stained using immunohistochemistry with polyclonal antibodies directed towards COX-1, COX-2, EP1, EP2, EP3, and EP4 [20].
  • Spinal COX-1 inhibition completely restores exploratory activity, including rearing behavior that stretches the abdominal muscles [5].

Associations of mt-Co1 with chemical compounds

  • There is a correlation (correlation coefficient = 0.05) between NOS activity and PGE(2) generation through the activation of phosphoinositide by phospholipase C (PLC), phospholipase A(2) (PLA(2)), and cyclooxygenase 1 (COX-1) [21].
  • Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone [22].
  • In contrast, 2-[2-(3-fluorophenyl)ethynyl]benzenesulfonamide (11c) possessing a SO2NH2 COX-2 pharmacophore at the ortho-position of the C-1 phenyl ring exhibited COX-1 inhibition and selectivity (COX-1 IC50=3.6 microM) [23].
  • Therefore the two metabolites of arachidonic acid seemed to be produced via an enzymatic COX1-dependent pathway [1].
  • COX function was assessed using COX activity inhibitors: indomethacin (INDO; COX1 and COX2 inhibitor) and NS-398 (COX2 selective inhibitor) [14].

Other interactions of mt-Co1


Analytical, diagnostic and therapeutic context of mt-Co1


  1. Cyclooxygenase 1-dependent production of F2-isoprostane and changes in redox status during warm renal ischemia-reperfusion. Favreau, F., Petit-Paris, I., Hauet, T., Dutheil, D., Papet, Y., Mauco, G., Tallineau, C. Free Radic. Biol. Med. (2004) [Pubmed]
  2. Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries. Fischer, J.W., Hawkins, S., Clowes, A.W. J. Vasc. Surg. (2004) [Pubmed]
  3. Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. Opay, A.L., Mouton, C.R., Mullins, J.J., Mitchell, K.D. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  4. Ontogenic changes in the expression of cytochrome c oxidase subunit I gene in the cerebellar cortex of the perinatal hypothyroid rat. Koibuchi, N., Matsuzaki, S., Ichimura, K., Ohtake, H., Yamaoka, S. Endocrinology (1996) [Pubmed]
  5. Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Martin, T.J., Buechler, N.L., Eisenach, J.C. Anesth. Analg. (2006) [Pubmed]
  6. Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Virbasius, J.V., Scarpulla, R.C. Mol. Cell. Biol. (1991) [Pubmed]
  7. Complete nucleotide sequence of the gene encoding rat cytochrome c oxidase subunit IV. Amuro, N., Yamada, M., Goto, Y., Okazaki, T. Nucleic Acids Res. (1990) [Pubmed]
  8. The rat cytochrome c oxidase subunit IV gene family: tissue-specific and hormonal differences in subunit IV and cytochrome c mRNA expression. Virbasius, J.V., Scarpulla, R.C. Nucleic Acids Res. (1990) [Pubmed]
  9. Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat. Cheung, K.H., Leung, G.P., Leung, M.C., Shum, W.W., Zhou, W.L., Wong, P.Y. J. Gen. Physiol. (2005) [Pubmed]
  10. Myocardial protection by pioglitazone, atorvastatin, and their combination: mechanisms and possible interactions. Ye, Y., Lin, Y., Atar, S., Huang, M.H., Perez-Polo, J.R., Uretsky, B.F., Birnbaum, Y. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  11. Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Lin, H., Lin, T.N., Cheung, W.M., Nian, G.M., Tseng, P.H., Chen, S.F., Chen, J.J., Shyue, S.K., Liou, J.Y., Wu, C.W., Wu, K.K. Circulation (2002) [Pubmed]
  12. A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity. Barrett, T., Xie, T., Piao, Y., Dillon-Carter, O., Kargul, G.J., Lim, M.K., Chrest, F.J., Wersto, R., Rowley, D.L., Juhaszova, M., Zhou, L., Vawter, M.P., Becker, K.G., Cheadle, C., Wood, W.H., McCann, U.D., Freed, W.J., Ko, M.S., Ricaurte, G.A., Donovan, D.M. Neurobiol. Dis. (2001) [Pubmed]
  13. MAPK and SRC-kinases control EGR-1 and NF-kappa B inductions by changes in mechanical environment in osteoblasts. Granet, C., Boutahar, N., Vico, L., Alexandre, C., Lafage-Proust, M.H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha, -1beta, and IL-6 mRNA levels in Leydig cell progenitors. Walch, L., Morris, P.L. Endocrinology (2002) [Pubmed]
  15. The possible role of isoforms of cytochrome c oxidase subunit VIa in mammalian thermogenesis. Hüttemann, M., Frank, V., Kadenbach, B. Cell. Mol. Life Sci. (1999) [Pubmed]
  16. Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Terman, A., Dalen, H., Eaton, J.W., Neuzil, J., Brunk, U.T. Exp. Gerontol. (2003) [Pubmed]
  17. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Romero-Sandoval, E.A., Molina, C., Alique, M., Moreno-Manzano, V., Lucio, F.J., Herrero, J.F. Br. J. Pharmacol. (2006) [Pubmed]
  18. Factors Involved in Upregulation of Inducible Nitric Oxide Synthase in Rat Small Intestine Following Administration of Nonsteroidal Anti-inflammatory Drugs. Takeuchi, K., Yokota, A., Tanaka, A., Takahira, Y. Dig. Dis. Sci. (2006) [Pubmed]
  19. Transforming growth factor beta1 regulates the expression of cyclooxygenase in cultured cortical astrocytes and neurons. Luo, J., Lang, J.A., Miller, M.W. J. Neurochem. (1998) [Pubmed]
  20. Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ--prostaglandin E2 dependent proliferation of growth plate chondrocytes. Brochhausen, C., Neuland, P., Kirkpatrick, C.J., Nüsing, R.M., Klaus, G. Arthritis Res. Ther. (2006) [Pubmed]
  21. Nitric Oxide Synthase and PGE(2) Reciprocal Interactions in Rat Dental Pulp: Cholinoceptor Modulation. Borda, E., Furlan, C., Orman, B., Reina, S., Sterin-Borda, L. Journal of endodontics (2007) [Pubmed]
  22. Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone. Sheehan, T.E., Kumar, P.A., Hood, D.A. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  23. Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors. Anana, R., Rao, P.N., Chen, Q.H., Knaus, E.E. Bioorg. Med. Chem. (2006) [Pubmed]
  24. PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. Hsieh, Y.C., Yang, S., Choudhry, M.A., Yu, H.P., Rue, L.W., Bland, K.I., Chaudry, I.H. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  25. Downregulation of ATP synthase subunit-6, cytochrome c oxidase-III, and NADH dehydrogenase-3 by bright cyclic light in the rat retina. Huang, H., Li, F., Alvarez, R.A., Ash, J.D., Anderson, R.E. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  26. Content of mitochondrial DNA and of three mitochondrial RNAs in developing and adult rat cerebellum. Renis, M., Cantatore, P., Loguercio Polosa, P., Fracasso, F., Gadaleta, M.N. J. Neurochem. (1989) [Pubmed]
  27. Thyromimetic action of the peroxisome proliferators clofibrate, perfluorooctanoic acid, and acetylsalicylic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis. Cai, Y., Nelson, B.D., Li, R., Luciakova, K., dePierre, J.W. Arch. Biochem. Biophys. (1996) [Pubmed]
  28. EGP-314 is expressed differentially in three brain zones at an early time in an experimentally induced ischemia rat model. Ortiz-Plata, A., Nader-Kawachi, J., Guevara, J., Sandoval, C., Rembao, D., de la Cruz Hernandez-Hernandez, F. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  29. Bigenomic functional regulation of all 13 cytochrome c oxidase subunit transcripts in rat neurons in vitro and in vivo. Liang, H.L., Ongwijitwat, S., Wong-Riley, M.T. Neuroscience (2006) [Pubmed]
  30. Effect of perinatal hypothyroidism on expression of cytochrome c oxidase subunit I gene, which is cloned by differential plaque screening from the cerebellum of newborn rat. Koibuchi, N., Matsuzaki, S., Ichimura, K., Ohtake, H., Yamaoka, S. J. Neuroendocrinol. (1995) [Pubmed]
  31. Cell-free synthesis of a larger-molecular-weight precursor of cytochrome c oxidase subunit V from rat liver and the distribution of its mRNA between free and membrane-bound polysomes. Schmelzer, E., Northemann, W., Kadenbach, B., Heinrich, P.C. Eur. J. Biochem. (1982) [Pubmed]
  32. Functional and cellular interactions between nitric oxide and prostacyclin. Marcelín-Jiménez, G., Escalante, B. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2001) [Pubmed]
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