Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cd209d - CD209d antigen

Mus musculus

Synonyms: CD209 antigen-like protein D, DC-SIGN-related protein 3, DC-SIGNR3, SIGN-R3, SIGNR3, ...

Galustian, C. et al., Powlesland, A.S. et al.

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High impact information on Cd209d

Results from screening of a glycan array demonstrate that only mouse SIGNR3 shares with human DC-SIGN the ability to bind both high mannose and fucose-terminated glycans in this format and to mediate endocytosis [1].
Here we use carbohydrate arrays as a new approach to discovering the ligands of three recently described C-type lectin-type receptors on antigen-presenting cells: murine SIGN-R1, SIGN-R3 and langerin [2].
High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin [2].

Associations of Cd209d with chemical compounds

The dominant specificities found for SIGN-R1 and SIGN-R3 are mannose- and fucose-related, as expressed on high mannose type N-glycans and Lewis(a/b)/Lewis(x/y)-type sequences, respectively, with subtle differences between the receptors [2].

References

Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. Powlesland, A.S., Ward, E.M., Sadhu, S.K., Guo, Y., Taylor, M.E., Drickamer, K. J. Biol. Chem. (2006) [Pubmed]
High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin. Galustian, C., Park, C.G., Chai, W., Kiso, M., Bruening, S.A., Kang, Y.S., Steinman, R.M., Feizi, T. Int. Immunol. (2004) [Pubmed]

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