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Gene Review

CD209  -  CD209 molecule

Homo sapiens

Synonyms: C-type lectin domain family 4 member L, CD209 antigen, CDSIGN, CLEC4L, DC-SIGN, ...
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Disease relevance of CD209


Psychiatry related information on CD209


High impact information on CD209


Chemical compound and disease context of CD209


Biological context of CD209

  • Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they directly recognize a plethora of pathogens, including bacteria, viruses, and parasites [14].
  • DC-SIGN (dendritic cell specific intracellular adhesion molecule 3 grabbing non-integrin) or CD209 is a type II transmembrane protein and one of several C-type lectin receptors expressed by dendritic cell subsets, which bind to high mannose glycoproteins promoting their endocytosis and potential degradation [15].
  • However, DC-specific ICAM-3-grabbing nonintegrin (CD209) up-regulation was not affected by cyclic nucleotides, indicating that DC development was not blocked at the monocyte stage [16].
  • Instead, phagocytosis of GC and E. coli by DCs is mediated by the DC-specific intercellular adhesion molecule-grabbing nonintegrin, (SIGN; CD209) receptor [17].
  • The DC-SIGN and DC-SIGNR genes map within a 30-kb region on chromosome 19p13.2-3 [18].

Anatomical context of CD209


Associations of CD209 with chemical compounds

  • However, pre-incubation of virus with MBL blocked DC-SIGN-mediated binding to cells, suggesting that the two lectins bind at the same or overlapping sites on the Ebola glycoprotein [23].
  • Disaccharide competitors and glycan chip analysis showed that DC-SIGN has a preference for oligosaccharides linked in an alpha-anomeric configuration [24].
  • Although the integrin LFA-1 is a counter-receptor for both ICAM-2 and ICAM-3, on DC, DC-SIGN is the high affinity adhesion receptor for ICAM-2/-3 [25].
  • Alanine-scanning mutagenesis of DC-SIGN revealed that highly conserved residues that coordinate calcium (Asp-366) and/or are involved in both calcium and specific carbohydrate interactions (Glu-347, Asn-349, Glu-354, and Asp-355) significantly compromised binding to all three ligands [24].
  • Monosaccharides with equatorial 4-OH groups competed as well as D-mannose for gp120 binding to DC-SIGN, regardless of how the other hydroxyl groups were positioned [24].

Physical interactions of CD209


Co-localisations of CD209


Regulatory relationships of CD209


Other interactions of CD209


Analytical, diagnostic and therapeutic context of CD209


  1. A variant in the CD209 promoter is associated with severity of dengue disease. Sakuntabhai, A., Turbpaiboon, C., Casadémont, I., Chuansumrit, A., Lowhnoo, T., Kajaste-Rudnitski, A., Kalayanarooj, S.M., Tangnararatchakit, K., Tangthawornchaikul, N., Vasanawathana, S., Chaiyaratana, W., Yenchitsomanus, P.T., Suriyaphol, P., Avirutnan, P., Chokephaibulkit, K., Matsuda, F., Yoksan, S., Jacob, Y., Lathrop, G.M., Malasit, P., Desprès, P., Julier, C. Nat. Genet. (2005) [Pubmed]
  2. Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells. Cambi, A., de Lange, F., van Maarseveen, N.M., Nijhuis, M., Joosten, B., van Dijk, E.M., de Bakker, B.I., Fransen, J.A., Bovee-Geurts, P.H., van Leeuwen, F.N., Van Hulst, N.F., Figdor, C.G. J. Cell Biol. (2004) [Pubmed]
  3. Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. Moris, A., Pajot, A., Blanchet, F., Guivel-Benhassine, F., Salcedo, M., Schwartz, O. Blood (2006) [Pubmed]
  4. The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin). Davis, C.W., Mattei, L.M., Nguyen, H.Y., Ansarah-Sobrinho, C., Doms, R.W., Pierson, T.C. J. Biol. Chem. (2006) [Pubmed]
  5. DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. Rappocciolo, G., Jenkins, F.J., Hensler, H.R., Piazza, P., Jais, M., Borowski, L., Watkins, S.C., Rinaldo, C.R. J. Immunol. (2006) [Pubmed]
  6. Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO. Nair, M.P., Schwartz, S.A., Mahajan, S.D., Tsiao, C., Chawda, R.P., Whitney, R., Don Sykes, B.B., Hewitt, R. J. Neuroimmunol. (2004) [Pubmed]
  7. Towards a crucial role for DC-SIGN in tuberculosis and beyond. Neyrolles, O., Gicquel, B., Quintana-Murci, L. Trends Microbiol. (2006) [Pubmed]
  8. The Immunobiology of SARS (*). Chen, J., Subbarao, K. Annu. Rev. Immunol. (2007) [Pubmed]
  9. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Pokidysheva, E., Zhang, Y., Battisti, A.J., Bator-Kelly, C.M., Chipman, P.R., Xiao, C., Gregorio, G.G., Hendrickson, W.A., Kuhn, R.J., Rossmann, M.G. Cell (2006) [Pubmed]
  10. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Geijtenbeek, T.B., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C., Adema, G.J., van Kooyk, Y., Figdor, C.G. Cell (2000) [Pubmed]
  11. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Cormier, E.G., Durso, R.J., Tsamis, F., Boussemart, L., Manix, C., Olson, W.C., Gardner, J.P., Dragic, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  12. Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1. Lue, J., Hsu, M., Yang, D., Marx, P., Chen, Z., Cheng-Mayer, C. J. Virol. (2002) [Pubmed]
  13. The core lipopolysaccharide of Escherichia coli is a ligand for the dendritic-cell-specific intercellular adhesion molecule nonintegrin CD209 receptor. Klena, J., Zhang, P., Schwartz, O., Hull, S., Chen, T. J. Bacteriol. (2005) [Pubmed]
  14. The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region. Barreiro, L.B., Patin, E., Neyrolles, O., Cann, H.M., Gicquel, B., Quintana-Murci, L. Am. J. Hum. Genet. (2005) [Pubmed]
  15. Proteomic analysis of DC-SIGN on dendritic cells detects tetramers required for ligand binding but no association with CD4. Bernhard, O.K., Lai, J., Wilkinson, J., Sheil, M.M., Cunningham, A.L. J. Biol. Chem. (2004) [Pubmed]
  16. Cyclic nucleotides promote monocyte differentiation toward a DC-SIGN+ (CD209) intermediate cell and impair differentiation into dendritic cells. Giordano, D., Magaletti, D.M., Clark, E.A., Beavo, J.A. J. Immunol. (2003) [Pubmed]
  17. DC-SIGN (CD209) recognition of Neisseria gonorrhoeae is circumvented by lipooligosaccharide variation. Zhang, P., Schwartz, O., Pantelic, M., Li, G., Knazze, Q., Nobile, C., Radovich, M., He, J., Hong, S.C., Klena, J., Chen, T. J. Leukoc. Biol. (2006) [Pubmed]
  18. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. Bashirova, A.A., Geijtenbeek, T.B., van Duijnhoven, G.C., van Vliet, S.J., Eilering, J.B., Martin, M.P., Wu, L., Martin, T.D., Viebig, N., Knolle, P.A., KewalRamani, V.N., van Kooyk, Y., Carrington, M. J. Exp. Med. (2001) [Pubmed]
  19. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. Tassaneetrithep, B., Burgess, T.H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M.A., Pattanapanyasat, K., Sarasombath, S., Birx, D.L., Steinman, R.M., Schlesinger, S., Marovich, M.A. J. Exp. Med. (2003) [Pubmed]
  20. HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood. Granelli-Piperno, A., Shimeliovich, I., Pack, M., Trumpfheller, C., Steinman, R.M. J. Immunol. (2006) [Pubmed]
  21. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. Granelli-Piperno, A., Pritsker, A., Pack, M., Shimeliovich, I., Arrighi, J.F., Park, C.G., Trumpfheller, C., Piguet, V., Moran, T.M., Steinman, R.M. J. Immunol. (2005) [Pubmed]
  22. Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells. Mansour, M.K., Latz, E., Levitz, S.M. J. Immunol. (2006) [Pubmed]
  23. Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization. Ji, X., Olinger, G.G., Aris, S., Chen, Y., Gewurz, H., Spear, G.T. J. Gen. Virol. (2005) [Pubmed]
  24. DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3. Su, S.V., Hong, P., Baik, S., Negrete, O.A., Gurney, K.B., Lee, B. J. Biol. Chem. (2004) [Pubmed]
  25. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. van Kooyk, Y., Geijtenbeek, T.B. Immunol. Rev. (2002) [Pubmed]
  26. CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. Bogoevska, V., Horst, A., Klampe, B., Lucka, L., Wagener, C., Nollau, P. Glycobiology (2006) [Pubmed]
  27. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe? Soilleux, E.J. Clin. Sci. (2003) [Pubmed]
  28. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Kwon, D.S., Gregorio, G., Bitton, N., Hendrickson, W.A., Littman, D.R. Immunity (2002) [Pubmed]
  29. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. Soilleux, E.J., Morris, L.S., Leslie, G., Chehimi, J., Luo, Q., Levroney, E., Trowsdale, J., Montaner, L.J., Doms, R.W., Weissman, D., Coleman, N., Lee, B. J. Leukoc. Biol. (2002) [Pubmed]
  30. Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells. van Lent, P.L., Figdor, C.G., Barrera, P., van Ginkel, K., Slöetjes, A., van den Berg, W.B., Torensma, R. Arthritis Rheum. (2003) [Pubmed]
  31. Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. Ludwig, I.S., Lekkerkerker, A.N., Depla, E., Bosman, F., Musters, R.J., Depraetere, S., van Kooyk, Y., Geijtenbeek, T.B. J. Virol. (2004) [Pubmed]
  32. Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. Geijtenbeek, T.B., van Duijnhoven, G.C., van Vliet, S.J., Krieger, E., Vriend, G., Figdor, C.G., van Kooyk, Y. J. Biol. Chem. (2002) [Pubmed]
  33. cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor. Lee, B., Leslie, G., Soilleux, E., O'Doherty, U., Baik, S., Levroney, E., Flummerfelt, K., Swiggard, W., Coleman, N., Malim, M., Doms, R.W. J. Virol. (2001) [Pubmed]
  34. Measles virus targets DC-SIGN to enhance dendritic cell infection. de Witte, L., Abt, M., Schneider-Schaulies, S., van Kooyk, Y., Geijtenbeek, T.B. J. Virol. (2006) [Pubmed]
  35. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Gringhuis, S.I., den Dunnen, J., Litjens, M., van Het Hof, B., van Kooyk, Y., Geijtenbeek, T.B. Immunity (2007) [Pubmed]
  36. Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes. Colmenares, M., Puig-Kröger, A., Pello, O.M., Corbí, A.L., Rivas, L. J. Biol. Chem. (2002) [Pubmed]
  37. DC-SIGN Facilitates Fusion of Dendritic Cells with Human T-Cell Leukemia Virus Type 1-Infected Cells. Ceccaldi, P.E., Delebecque, F., Prevost, M.C., Moris, A., Abastado, J.P., Gessain, A., Schwartz, O., Ozden, S. J. Virol. (2006) [Pubmed]
  38. Dendritic cells fused with core binding factor-beta positive acute myeloid leukaemia blast cells induce activation of cytotoxic lymphocytes. Banat, G.A., Usluoglu, N., Hoeck, M., Ihlow, K., Hoppmann, S., Pralle, H. Br. J. Haematol. (2004) [Pubmed]
  39. PU.1 regulates the tissue-specific expression of dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin. Domínguez-Soto, A., Puig-Kröger, A., Vega, M.A., Corbí, A.L. J. Biol. Chem. (2005) [Pubmed]
  40. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. Mitchell, D.A., Fadden, A.J., Drickamer, K. J. Biol. Chem. (2001) [Pubmed]
  41. Intrahepatic gene expression in human alcoholic hepatitis. Seth, D., Gorrell, M.D., Cordoba, S., McCaughan, G.W., Haber, P.S. J. Hepatol. (2006) [Pubmed]
  42. Infantile hemangioma is a proliferation of beta 4-negative endothelial cells adjacent to HLA-DR-positive cells with dendritic cell morphology. Nguyen, V.A., Fürhapter, C., Romani, N., Weber, F., Sepp, N. Hum. Pathol. (2004) [Pubmed]
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