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Gene Review:

Ndrg2 - NDRG family member 2

Rattus norvegicus

Synonyms: Antidepressant-related protein ADRG123, N-myc downstream-regulated gene 2 protein, NDRG1-related protein, Protein NDRG2

Takahashi, K. et al., Wielpütz, M.O. et al.

Yamada, Takahashi, Ohata, Yamada, Honda,

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High impact information on Ndrg2

The functional role of Ndrg2 in the central nervous system, however, remains unclear [1].
In the present study, we examined the expression of endogenous Ndrg2, cellular localization of transfected Ndrg2 protein, and morphological changes resulting from overexpression of Ndrg2 in NGF-differentiated PC12 cells [1].
Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells [1].
Ndrg2 is a member of the N-myc downstream-regulated genes [1].

Associations of Ndrg2 with chemical compounds

Our results indicate that NDRG2 is a likely candidate to contribute to aldosterone-mediated ENaC regulation [2].

Analytical, diagnostic and therapeutic context of Ndrg2

During this time, we evaluated Ndrg2 mRNA expression by real-time quantitative PCR and found that expression significantly increased in a time-dependent manner [1].

References

Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells. Takahashi, K., Yamada, M., Ohata, H., Honda, K., Yamada, M. Neurosci. Lett. (2005) [Pubmed]
(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells. Wielpütz, M.O., Lee, I.H., Dinudom, A., Boulkroun, S., Farman, N., Cook, D.I., Korbmacher, C., Rauh, R. J. Biol. Chem. (2007) [Pubmed]

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NDL2	Arabidopsis thaliana
NDRG2	Bos taurus
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ndrg2	Danio rerio
NDRG2	Homo sapiens
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ndrg2	Xenopus (Silurana) tropicalis

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