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Gene Review

NDRG2  -  NDRG family member 2

Homo sapiens

Synonyms: KIAA1248, N-myc downstream-regulated gene 2 protein, Protein NDRG2, Protein Syld709613, SYLD
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Disease relevance of NDRG2

  • In addition, these findings highlight the utility of combining genomic, epigenetic, and expression data to identify clinically significant tumor biomarkers, and suggest that NDRG2 expression will be a useful and functionally relevant biomarker to predict aggressive behavior in patients with meningioma [1].
  • N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation [2].
  • NDRG2 expression and mutation in human liver and pancreatic cancers [3].
  • RESULTS: Compared with adjacent normal tissues, the expression levels of NDRG2 mRNA in corresponding cancer tissues reduced significantly (pancreatic cancer: 0.680+/-0.112 vs 2.089+/-0.214, P<0.01) (liver cancer: 0.894+/-0.098 vs 1.345+/-0.177, P<0.05) [3].

Psychiatry related information on NDRG2


High impact information on NDRG2


Biological context of NDRG2


Anatomical context of NDRG2

  • Expression of the fusion proteins NDRG2/GFP, NDRG3/GFP and NDRG4/GFP in COS-7 cells showed that all of them are cytosolic proteins [7].
  • We searched for genes with expressions specific to human monocyte-derived dendritic cells (DCs) using differential display reverse transcription-polymerase chain reaction, and found that N-myc downstream regulated gene 2 (NDRG2), a member of a new family of differentiation-related genes, was expressed in DCs [8].
  • While DCs derived from CD34(+) progenitor cells also showed strong NDRG2 expression, the corresponding mRNA expression was absent in other cell lines including monocytes, B cells, and NK cells [8].
  • Expression of NDRG2 in affected brains was revealed in (1) cortical pyramidal neurons, (2) senile plaques and (3) cellular processes of dystrophic neurons [4].
  • Semiquantitative RT-PCR showed that the hNDRG2 gene transcript is expressed in normal brain tissue and low-grade gliomas but is present at low levels in 15 of 27 (56%) human GBM tissues and all of the 6 human glioblastoma cell lines examined [2].

Associations of NDRG2 with chemical compounds

  • The inhibition of DC differentiation by dexamethasone or vitamin D(3) treatment down-regulated the expression of the NDRG2 gene in DCs [8].
  • Taken together, these results indicate that NDRG2 regulation by aldosterone is an early mineralocorticoid-specific effect [9].
  • Furthermore, real-time PCR on microdissected tubules revealed that the decrease in NDRG2 expression caused by DHT is restricted to the CCD [10].
  • Expression of androgen receptor and androgen regulation of NDRG2 in the rat renal collecting duct [10].
  • In the present study, we demonstrated that chronic treatment with a tricyclic antidepressant (imipramine) and a selective serotonin reuptake inhibitor (sertraline) reduced the expression of Ndrg2 mRNA and protein in the rat frontal cortex [11].

Enzymatic interactions of NDRG2


Other interactions of NDRG2


Analytical, diagnostic and therapeutic context of NDRG2


  1. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Lusis, E.A., Watson, M.A., Chicoine, M.R., Lyman, M., Roerig, P., Reifenberger, G., Gutmann, D.H., Perry, A. Cancer Res. (2005) [Pubmed]
  2. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Deng, Y., Yao, L., Chau, L., Ng, S.S., Peng, Y., Liu, X., Au, W.S., Wang, J., Li, F., Ji, S., Han, H., Nie, X., Li, Q., Kung, H.F., Leung, S.Y., Lin, M.C. Int. J. Cancer (2003) [Pubmed]
  3. NDRG2 expression and mutation in human liver and pancreatic cancers. Hu, X.L., Liu, X.P., Lin, S.X., Deng, Y.C., Liu, N., Li, X., Yao, L.B. World J. Gastroenterol. (2004) [Pubmed]
  4. NDRG2: a novel Alzheimer's disease associated protein. Mitchelmore, C., Büchmann-Møller, S., Rask, L., West, M.J., Troncoso, J.C., Jensen, N.A. Neurobiol. Dis. (2004) [Pubmed]
  5. The Repression of Human Differentiation-related Gene NDRG2 Expression by Myc via Miz-1-dependent Interaction with the NDRG2 Core Promoter. Zhang, J., Li, F., Liu, X., Shen, L., Liu, J., Su, J., Zhang, W., Deng, Y., Wang, L., Liu, N., Han, W., Zhang, J., Ji, S., Yang, A., Han, H., Yao, L. J. Biol. Chem. (2006) [Pubmed]
  6. Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta. Burchfield, J.G., Lennard, A.J., Narasimhan, S., Hughes, W.E., Wasinger, V.C., Corthals, G.L., Okuda, T., Kondoh, H., Biden, T.J., Schmitz-Peiffer, C. J. Biol. Chem. (2004) [Pubmed]
  7. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Qu, X., Zhai, Y., Wei, H., Zhang, C., Xing, G., Yu, Y., He, F. Mol. Cell. Biochem. (2002) [Pubmed]
  8. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. Choi, S.C., Kim, K.D., Kim, J.T., Kim, J.W., Yoon, D.Y., Choe, Y.K., Chang, Y.S., Paik, S.G., Lim, J.S. FEBS Lett. (2003) [Pubmed]
  9. Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. Boulkroun, S., Fay, M., Zennaro, M.C., Escoubet, B., Jaisser, F., Blot-Chabaud, M., Farman, N., Courtois-Coutry, N. J. Biol. Chem. (2002) [Pubmed]
  10. Expression of androgen receptor and androgen regulation of NDRG2 in the rat renal collecting duct. Boulkroun, S., Le Moellic, C., Blot-Chabaud, M., Farman, N., Courtois-Coutry, N. Pflugers Arch. (2005) [Pubmed]
  11. Expression of Ndrg2 in the rat frontal cortex after antidepressant and electroconvulsive treatment. Takahashi, K., Yamada, M., Ohata, H., Momose, K., Higuchi, T., Honda, K., Yamada, M. Int. J. Neuropsychopharmacol. (2005) [Pubmed]
  12. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Murray, J.T., Campbell, D.G., Morrice, N., Auld, G.C., Shpiro, N., Marquez, R., Peggie, M., Bain, J., Bloomberg, G.B., Grahammer, F., Lang, F., Wulff, P., Kuhl, D., Cohen, P. Biochem. J. (2004) [Pubmed]
  13. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Zhou, R.H., Kokame, K., Tsukamoto, Y., Yutani, C., Kato, H., Miyata, T. Genomics (2001) [Pubmed]
  14. Ndrg2, a novel gene regulated by adrenal steroids and antidepressants, is highly expressed in astrocytes. Nichols, N.R. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
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