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Gene Review

Mab21l1  -  mab-21-like 1 (C. elegans)

Mus musculus

Synonyms: AW047968, Mab21, Protein mab-21-like 1
 
 
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High impact information on Mab21l1

  • It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologs, Mab21l1 and Mab21l2, have been identified in many species [1].
  • We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner [1].
  • In addition, Mab21l1 had unique expression in the lens vesicles and genital tubercle whereas Mab21l2 was expressed in the retinal epithelium and umbilical cord [2].
 

Biological context of Mab21l1

 

Anatomical context of Mab21l1

  • Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation [2].
 

Analytical, diagnostic and therapeutic context of Mab21l1

References

  1. Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., Takahashi, N. Development (2003) [Pubmed]
  2. Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation. Wong, R.L., Chow, K.L. Teratology (2002) [Pubmed]
  3. Developmental expression of Mab21l2 during mouse embryogenesis. Wong, R.L., Chan, K.K., Chow, K.L. Mech. Dev. (1999) [Pubmed]
 
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