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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mxd4  -  Max dimerization protein 4

Mus musculus

Synonyms: 2810410A03Rik, Mad4, Max dimerizer 4, Max-associated protein 4, Max-interacting transcriptional repressor MAD4, ...
 
 
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High impact information on Mxd4

  • Mxi1 and Mad4 transcripts are most abundant in cells that have further advanced along the differentiation pathway, whereas Mad1 is primarily expressed late in differentiation [1].
  • More importantly, we found that TGF-beta1 induces the expression of the putative tumor suppressor genes Mad4 and Mxi1 in both the Balb/MK and Mv1Lu cell lines [2].

References

  1. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Quéva, C., Hurlin, P.J., Foley, K.P., Eisenman, R.N. Oncogene (1998) [Pubmed]
  2. TGF-beta1 regulates the expression of multiple max-interacting transcription factors in Balb/MK cells: implications for understanding the mechanism of action of TGF-beta1. Satterwhite, D.J., White, R.L., Aakre, M.E., Moses, H.L. Pediatr. Res. (2001) [Pubmed]
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