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Gene Review

mab-20  -  Protein MAB-20

Caenorhabditis elegans

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High impact information on mab-20

  • A feature of smp-1 mutants that is shared with mutants of mab-20 (which encodes Sema-2a) is the abnormal perdurance of contacts between epidermal cells [1].
  • Suppression of C. elegans transmembrane semaphorins, Ce-Sema-1a and Ce-Sema-1b, by RNA interference caused a displacement of ray 1 similar to that of plx-1 mutants, whereas mutants for the Ce-Sema-2a/mab-20 gene, which encodes a secreted-type semaphorin, exhibited phenotypes distinct from those of plx-1 mutants [2].
  • In addition to low-frequency axon guidance errors, mab-20 mutants have unexpected defects in epidermal morphogenesis [3].
  • In efn-4 and mab-20 mutants, ectopic contacts form between cells belonging to different rays [4].
  • Genetic analyses show that plx-2 and mab-20 function in the same pathway, as expected if PLX-2 is a receptor for MAB-20 [5].

Biological context of mab-20


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