Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

mab-20 - Protein MAB-20

Caenorhabditis elegans

Fujii, T. et al., Ikegami, R. et al., Ginzburg, V.E. et al., Roy, P.J. et al., Hahn, A.C. et al.

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High impact information on mab-20

A feature of smp-1 mutants that is shared with mutants of mab-20 (which encodes Sema-2a) is the abnormal perdurance of contacts between epidermal cells [1].
Suppression of C. elegans transmembrane semaphorins, Ce-Sema-1a and Ce-Sema-1b, by RNA interference caused a displacement of ray 1 similar to that of plx-1 mutants, whereas mutants for the Ce-Sema-2a/mab-20 gene, which encodes a secreted-type semaphorin, exhibited phenotypes distinct from those of plx-1 mutants [2].
In addition to low-frequency axon guidance errors, mab-20 mutants have unexpected defects in epidermal morphogenesis [3].
In efn-4 and mab-20 mutants, ectopic contacts form between cells belonging to different rays [4].
Genetic analyses show that plx-2 and mab-20 function in the same pathway, as expected if PLX-2 is a receptor for MAB-20 [5].

Biological context of mab-20

Several erf (enhancer of ray fusion) mutations were identified in a mab-20 enhancer screen [5].

References

Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg, V.E., Roy, P.J., Culotti, J.G. Development (2002) [Pubmed]
Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis. Fujii, T., Nakao, F., Shibata, Y., Shioi, G., Kodama, E., Fujisawa, H., Takagi, S. Development (2002) [Pubmed]
mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans. Roy, P.J., Zheng, H., Warren, C.E., Culotti, J.G. Development (2000) [Pubmed]
The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development. Hahn, A.C., Emmons, S.W. Dev. Biol. (2003) [Pubmed]
Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. Ikegami, R., Zheng, H., Ong, S.H., Culotti, J. Dev. Cell (2004) [Pubmed]

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