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Gene Review

msh-6  -  Protein MSH-6

Caenorhabditis elegans

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High impact information on msh-6

  • In this study we examine mutation processes in base excision repair-deficient (nth-1) and nucleotide excision repair-deficient (xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of the genome and compare our observations to previous data from mismatch repair-deficient (msh-2 and msh-6) and wild-type (N2) MA lines [1].
  • In contrast to yeast and humans where mutation spectra vary substantially with respect to different specific MMR-deficient genotypes, mutation rates and patterns were overall highly similar between the msh-2 and msh-6 C. elegans MA lines [2].

Biological context of msh-6

  • RNA interference by feeding wild-type animals dsRNA homologous to msh-2 or msh-6 also resulted in somatic DNA instability, as well as in germline mutagenesis, indicating that one can use C. elegans as a model system to discover genes involved in maintaining DNA stability by large-scale RNAi screens [3].


  1. The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation. Denver, D.R., Feinberg, S., Steding, C., Durbin, M., Lynch, M. Genetics (2006) [Pubmed]
  2. Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Denver, D.R., Feinberg, S., Estes, S., Thomas, W.K., Lynch, M. Genetics (2005) [Pubmed]
  3. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Tijsterman, M., Pothof, J., Plasterk, R.H. Genetics (2002) [Pubmed]
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