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Gene Review:

msh-2 - Protein MSH-2

Caenorhabditis elegans

Degtyareva, N.P. et al., Denver, D.R. et al., Tijsterman, M. et al., Denver, D.R. et al.

Denver, Feinberg, Estes, Thomas, Lynch, Denver, Feinberg, Steding, Durbin, Lynch,

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High impact information on msh-2

Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity [1].
These results demonstrate that msh-2 function in C. elegans is important in regulating both short- and long-term genomic stability [1].
Early-passage msh-2 mutants were similar to wild-type worms with regard to lifespan and meiotic chromosome segregation but had slightly reduced fertility [1].
In this study we examine mutation processes in base excision repair-deficient (nth-1) and nucleotide excision repair-deficient (xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of the genome and compare our observations to previous data from mismatch repair-deficient (msh-2 and msh-6) and wild-type (N2) MA lines [2].
In contrast to yeast and humans where mutation spectra vary substantially with respect to different specific MMR-deficient genotypes, mutation rates and patterns were overall highly similar between the msh-2 and msh-6 C. elegans MA lines [3].

Biological context of msh-2

The msh-2 mutants also had elevated levels of microsatellite instability and increased rates of reversion of the dominant unc-58(e665) mutation [1].
RNA interference by feeding wild-type animals dsRNA homologous to msh-2 or msh-6 also resulted in somatic DNA instability, as well as in germline mutagenesis, indicating that one can use C. elegans as a model system to discover genes involved in maintaining DNA stability by large-scale RNAi screens [4].

References

Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. Degtyareva, N.P., Greenwell, P., Hofmann, E.R., Hengartner, M.O., Zhang, L., Culotti, J.G., Petes, T.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation. Denver, D.R., Feinberg, S., Steding, C., Durbin, M., Lynch, M. Genetics (2006) [Pubmed]
Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Denver, D.R., Feinberg, S., Estes, S., Thomas, W.K., Lynch, M. Genetics (2005) [Pubmed]
Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Tijsterman, M., Pothof, J., Plasterk, R.H. Genetics (2002) [Pubmed]

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