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Gene Review:

pgp-2 - Protein PGP-2

Caenorhabditis elegans

Nunes, F. et al., Lincke, C.R. et al.

Nunes, Wolf, Hartmann, Paul,

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High impact information on pgp-2

The genes were physically mapped on chromosome IV (pgp-1), I (pgp-2) and X (pgp-3 and pgp-4) [1].
The functional role of the ABC transporter PGP-2 from the nematode Caenorhabditis elegans has been studied by combining phenotype analyses of pgp-2 deletion mutants or pgp-2 RNAi treated worms with reporter gene studies using a pgp-2::GFP construct. pgp-2 mutants showed a strong reduction of lipid stores [2].
In addition, we found that in the case of the pgp-2 mutant or after pgp-2 RNAi the worms were unable to perform pinocytosis and to acidify intestinal lysosomes [2].

References

The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke, C.R., The, I., van Groenigen, M., Borst, P. J. Mol. Biol. (1992) [Pubmed]
The ABC transporter PGP-2 from Caenorhabditis elegans is expressed in the sensory neuron pair AWA and contributes to lysosome formation and lipid storage within the intestine. Nunes, F., Wolf, M., Hartmann, J., Paul, R.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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AgaP_AGAP005639	Anopheles gambiae str. PEST
PGP2	Arabidopsis thaliana
PGP10	Arabidopsis thaliana
Mdr49	Drosophila melanogaster
Abcb1b	Mus musculus
Os02g0693700	Oryza sativa Japonica Group
Abcb1b	Rattus norvegicus

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