The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Abcb1b  -  ATP-binding cassette, subfamily B...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family B member 1, Abcb1, Mdr1, Mdr1b, Multidrug resistance protein 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Abcb1b

  • Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure [1].
  • Reoxygenation of cell monolayers after 6 h hypoxia gave rise to a similar transient increase in iROS and this also led to increased Pgp expression by 24 h [2].
  • P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity [3].
  • Finally, the HIV protease inhibitors saquinavir and ritonavir were potent inhibitors of transport mediated by both P-glycoprotein and Mrp [4].
  • In conclusion, the induction of P-gp, leading to a decrease in lung levels of PQ and the consequent prevention of toxicity, seems to be a new and promising treatment for PQ poisonings that should be further clinically tested [3].

Psychiatry related information on Abcb1b


High impact information on Abcb1b


Chemical compound and disease context of Abcb1b


Biological context of Abcb1b


Anatomical context of Abcb1b


Associations of Abcb1b with chemical compounds


Physical interactions of Abcb1b


Regulatory relationships of Abcb1b

  • These results indicate that MRP is over-expressed and functional in rat hepatoma cells and may therefore be included in the de-toxifying pathways that are altered during hepatocarcinogenesis and are thus thought to contribute to the known multidrug resistance of liver tumors [23].

Other interactions of Abcb1b

  • Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2 [19].
  • Our data show that in the liver of both strains, exposure to a hypotonic medium stimulates DOX excretion, presumably by activation of P-gp and mrp2 during RVD [24].
  • Furthermore, in vivo administration of AAF, which maximally induces PGP does not induce MRP2 [25].
  • In contrast, LPS increased mRNA levels of Mrp1, Mrp3, and Mdr1b concurrently with the down-regulated transporters [26].
  • Positive AUC was found for ARG, ASL, CPT1, Mdr1b, Mdr2, and PEPCK [27].

Analytical, diagnostic and therapeutic context of Abcb1b


  1. Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure. Laouari, D., Yang, R., Veau, C., Blanke, I., Friedlander, G. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  2. P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress. Felix, R.A., Barrand, M.A. J. Neurochem. (2002) [Pubmed]
  3. P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity. Dinis-Oliveira, R.J., Remi??o, F., Duarte, J.A., Ferreira, R., S??nchez Navarro, A., Bastos, M.L., Carvalho, F. Free Radic. Biol. Med. (2006) [Pubmed]
  4. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Miller, D.S., Nobmann, S.N., Gutmann, H., Toeroek, M., Drewe, J., Fricker, G. Mol. Pharmacol. (2000) [Pubmed]
  5. Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Ronaldson, P.T., Lee, G., Dallas, S., Bendayan, R. Pharm. Res. (2004) [Pubmed]
  6. Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors. Rice, A., Michaelis, M.L., Georg, G., Liu, Y., Turunen, B., Audus, K.L. J. Mol. Neurosci. (2003) [Pubmed]
  7. Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. Lecoeur, S., Videmann, B., Mazallon, M. Toxicol. Lett. (2006) [Pubmed]
  8. Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Thorgeirsson, S.S., Huber, B.E., Sorrell, S., Fojo, A., Pastan, I., Gottesman, M.M. Science (1987) [Pubmed]
  9. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. Burt, R.K., Thorgeirsson, S.S. J. Natl. Cancer Inst. (1988) [Pubmed]
  10. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. van Waarde, W.M., Verkade, H.J., Wolters, H., Havinga, R., Baller, J., Bloks, V., Müller, M., Sauer, P.J., Kuipers, F. Gastroenterology (2002) [Pubmed]
  11. Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats. Shimizu, A., Miyoshi, M., Sugie, M., Ueyama, J., Yamaguchi, T., Sasaki, T., Takagi, K., Jin, M., Miyamoto, K., Tsuji, A., Hasegawa, T. Eur. J. Pharmacol. (2004) [Pubmed]
  12. Role of P-glycoprotein in tissue uptake of indinavir in rat. Hamidi, M. Life Sci. (2006) [Pubmed]
  13. Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier. van der Sandt, I.C., Vos, C.M., Nabulsi, L., Blom-Roosemalen, M.C., Voorwinden, H.H., de Boer, A.G., Breimer, D.D. AIDS (2001) [Pubmed]
  14. Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. Lo, Y.L. Journal of controlled release : official journal of the Controlled Release Society. (2003) [Pubmed]
  15. P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes. Mercier, C., Declèves, X., Masseguin, C., Fragner, P., Tardy, M., Roux, F., Gabrion, J., Scherrmann, J.M. J. Neurochem. (2003) [Pubmed]
  16. Contribution of mdr1b-type P-glycoprotein to okadaic acid resistance in rat pituitary GH3 cells. Ritz, V., Marwitz, J., Sieder, S., Ziemann, C., Hirsch-Ernst, K.I., Quentin, I., Steinfelder, H.J. Naunyn Schmiedebergs Arch. Pharmacol. (1999) [Pubmed]
  17. In Situ Localization of P-glycoprotein (ABCB1) in Human and Rat Brain. Bendayan, R., Ronaldson, P.T., Gingras, D., Bendayan, M. J. Histochem. Cytochem. (2006) [Pubmed]
  18. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. Booth-Genthe, C.L., Louie, S.W., Carlini, E.J., Li, B., Leake, B.F., Eisenhandler, R., Hochman, J.H., Mei, Q., Kim, R.B., Rushmore, T.H., Yamazaki, M. Journal of pharmacological and toxicological methods. (2006) [Pubmed]
  19. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. Patel, V.A., Dunn, M.J., Sorokin, A. J. Biol. Chem. (2002) [Pubmed]
  20. Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. Regina, A., Koman, A., Piciotti, M., El Hafny, B., Center, M.S., Bergmann, R., Couraud, P.O., Roux, F. J. Neurochem. (1998) [Pubmed]
  21. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Liu, J., Chen, H., Miller, D.S., Saavedra, J.E., Keefer, L.K., Johnson, D.R., Klaassen, C.D., Waalkes, M.P. Mol. Pharmacol. (2001) [Pubmed]
  22. Effects of colchicine and phenothiazine on biliary excretion of organic anions in rats. Takikawa, H., Sano, N., Akimoto, K., Ogasawara, T., Yamanaka, M. J. Gastroenterol. Hepatol. (1998) [Pubmed]
  23. The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells. Payen, L., Courtois, A., Vernhet, L., Guillouzo, A., Fardel, O. Int. J. Cancer (1999) [Pubmed]
  24. Influence of hypotonic stress on the biliary excretion of doxorubicin in Wistar and TR- rats. Gaugg, M., Haslmayer, P., Jäger, W., Thalhammer, T. Anticancer Res. (2001) [Pubmed]
  25. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. Tang, W., Yi, C., Kalitsky, J., Piquette-Miller, M. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
  26. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Cherrington, N.J., Slitt, A.L., Li, N., Klaassen, C.D. Drug Metab. Dispos. (2004) [Pubmed]
  27. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup, N., Bangert, K., Ott, P., Bisgaard, H.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  28. Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. Sugie, M., Asakura, E., Zhao, Y.L., Torita, S., Nadai, M., Baba, K., Kitaichi, K., Takagi, K., Takagi, K., Hasegawa, T. Antimicrob. Agents Chemother. (2004) [Pubmed]
  29. Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats. Seegers, U., Potschka, H., Löscher, W. Epilepsia (2002) [Pubmed]
  30. A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. Zhang, J., Huang, M., Guan, S., Bi, H.C., Pan, Y., Duan, W., Chan, S.Y., Chen, X., Hong, Y.H., Bian, J.S., Yang, H.Y., Zhou, S. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
WikiGenes - Universities