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Gene Review

ttx-7  -  Protein TTX-7

Caenorhabditis elegans

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High impact information on myo-inositol-1-monophosphatase

  • Both behavioral and localization defects in ttx-7 mutants were rescued by expression of IMPase in adults and by inositol application, and the same defects were mimicked by lithium treatment in wild-type animals [1].
  • In a screen for thermotaxis mutants, we identified the gene ttx-7, which encodes myo-inositol monophosphatase (IMPase), an inositol-producing enzyme regarded as a bipolar disorder-relevant molecule for its lithium sensitivity [1].
  • These results suggest that IMPase is required in central interneurons of the mature nervous system for correct localization of synaptic components and thus for normal behavior [1].


  1. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T., Mori, I. Genes Dev. (2006) [Pubmed]
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