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Gene Review

INM1  -  inositol monophosphate 1-phosphatase INM1

Saccharomyces cerevisiae S288c

Synonyms: IMP 1, IMP1, IMPase 1, Inositol monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, ...
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High impact information on INM1

  • However, it does not affect regulation of INM1 (encoding inositol monophosphatase), the expression of which is up-regulated by myo-inositol [1].
  • INM1 was determined by beta-galactosidase activity in a strain containing the fusion gene INM1-lacZintegrated into the genome [1].
  • Unlike all other phospholipid biosynthetic enzyme-encoding genes studied, which contain the UASINO regulatory element, INM1 expression is increased in the presence of inositol [2].
  • Both lithium and valproate, which cause a decrease in intracellular inositol, effect a decrease in INM1 expression [2].
  • In addition, INM1 expression was repressed during growth in glycerol and derepressed as glucose-grown cells entered stationary [2].

Associations of INM1 with chemical compounds


Other interactions of INM1


  1. Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase. Shaldubina, A., Ju, S., Vaden, D.L., Ding, D., Belmaker, R.H., Greenberg, M.L. Mol. Psychiatry (2002) [Pubmed]
  2. Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Murray, M., Greenberg, M.L. Mol. Microbiol. (2000) [Pubmed]
  3. Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs. Agam, G., Shamir, A., Shaltiel, G., Greenberg, M.L. Bipolar disorders. (2002) [Pubmed]
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