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Gene Review:

INM2 - inositol monophosphate 1-phosphatase INM2

Saccharomyces cerevisiae S288c

Synonyms: IMP 2, IMP2, IMPase 2, Inositol monophosphatase 2, Inositol-1(or 4)-monophosphatase 2, ...

Murray, M. et al., Ingavale, S.S. et al., Murray, M. et al., Shaldubina, A. et al., Lopez, F. et al.

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High impact information on YDR287W

However, it does not affect regulation of INM1 (encoding inositol monophosphatase), the expression of which is up-regulated by myo-inositol [1].
The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair [2].
Because the yeast Saccharomyces cerevisiae has been shown to be an excellent model system in which to understand the regulation of inositol metabolism, we characterized inositol monophosphatase in this yeast [3].
Inositol monophosphatase is a key enzyme in the de novo biosynthesis of inositol and in the phosphoinositide second-messenger signalling pathway [3].
The biosynthesis of inositol requires only two enzymes, inositol-1-phosphate synthase (encoded by INO1) and an inositol monophosphatase, but the regulation of inositol biosynthesis is under multiple controls and is exquisitely regulated [4].

Associations of YDR287W with chemical compounds

Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate [5].

References

Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase. Shaldubina, A., Ju, S., Vaden, D.L., Ding, D., Belmaker, R.H., Greenberg, M.L. Mol. Psychiatry (2002) [Pubmed]
The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Lopez, F., Leube, M., Gil-Mascarell, R., Navarro-Aviñó, J.P., Serrano, R. Mol. Microbiol. (1999) [Pubmed]
Regulation of inositol monophosphatase in Saccharomyces cerevisiae. Murray, M., Greenberg, M.L. Mol. Microbiol. (1997) [Pubmed]
Restoration of inositol prototrophy in the fission yeast Schizosaccharomyces pombe. Ingavale, S.S., Bachhawat, A.K. Microbiology (Reading, Engl.) (1999) [Pubmed]
Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Murray, M., Greenberg, M.L. Mol. Microbiol. (2000) [Pubmed]

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IMPA1	Bos taurus
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INM1	Saccharomyces cerevisiae S288c
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