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Gene Review

Impa1  -  Inositol (myo)-1(or 4)-monophosphatase 1

Rattus norvegicus

Synonyms: D-galactose 1-phosphate phosphatase, IMP 1, IMPase 1, Imp, Inositol monophosphatase 1, ...
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Psychiatry related information on Impa1


High impact information on Impa1

  • The long-term effects of lithium are not caused by down-regulation of NMDA receptor subunit proteins and are unlikely related to its known ability to block inositol monophosphatase activity [2].
  • The core fold of the enzyme is equivalent to that found in other Li(+)-sensitive phosphatases, such as inositol monophosphatase, but molecular modelling of I(1),(4)P(2) in the RnPIP active site reveals important structural determinants that accommodate this additional substrate [3].
  • 8. When Li+ was present during stimulation, it redirected the dephosphorylation pathways downstream of Ins(1,4,5)P3 in the manner expected from its inhibition of inositol monophosphatase and Ins(1,4)P2/Ins(1,3,4)P3 1-phosphatase: there were marked increases in the accumulation of Ins(1,4)P2 and Ins(1,3,4)P3 and of monophosphates [4].
  • Nucleoside diphosphatases [inosine diphosphatase (IDPase) and uridine diphosphatase (UDPase)] and nucleoside monophosphatases [uridine monophosphatase (UMPase) and inosine monophosphatase (IMPase)] were also determined [5].
  • We conclude that rat liver cytosol contains an Ins(1,4)P2 1-phosphatase that is distinct from, but in many ways similar to, inositol monophosphatase [6].

Biological context of Impa1


Anatomical context of Impa1

  • Both the qualitative and quantitative increases of IMPase 1 activity by chronic lithium treatment were substantiated by Western blot analysis of hippocampal and cerebral cortex regions [9].
  • These results demonstrate that stimulatory effects of lithium on glucose transport are not mediated by the inhibition of IMPase and subsequent accumulation of IP1 in rat adipocytes [10].
  • Under ether anesthesia a zirconium laminar implant was placed in the tibia following the method previously described by our laboratory (Cabrini et al Imp Dent 2:264-7, 1993) [11].

Associations of Impa1 with chemical compounds


Analytical, diagnostic and therapeutic context of Impa1

  • Using a range of quantitative binding assays including enzyme-linked immunosorbent assay, fluorescence polarization, and native gel mobility electrophoresis, we assess the binding of importins to SRY, demonstrating a high affinity recognition (in the low nm range) by Imp beta independent of Imp alpha [16].
  • The Ins(1,4)P2 1-phosphatase and inositol monophosphatase activities all share an apparent Mr of 47 x 10(3), as determined by gel-filtration chromatography [6].


  1. Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Brandish, P.E., Su, M., Holder, D.J., Hodor, P., Szumiloski, J., Kleinhanz, R.R., Forbes, J.E., McWhorter, M.E., Duenwald, S.J., Parrish, M.L., Na, S., Liu, Y., Phillips, R.L., Renger, J.J., Sankaranarayanan, S., Simon, A.J., Scolnick, E.M. Neuron (2005) [Pubmed]
  2. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Nonaka, S., Hough, C.J., Chuang, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. Patel, S., Yenush, L., Rodríguez, P.L., Serrano, R., Blundell, T.L. J. Mol. Biol. (2002) [Pubmed]
  4. The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells. Barker, C.J., Wong, N.S., Maccallum, S.M., Hunt, P.A., Michell, R.H., Kirk, C.J. Biochem. J. (1992) [Pubmed]
  5. Distribution of thiamine, thiamine phosphates, and thiamine metabolizing enzymes in neuronal and glial cell enriched fractions of rat brain. Laforenza, U., Patrini, C., Rindi, G. J. Neurochem. (1988) [Pubmed]
  6. Dephosphorylation of 1D-myo-inositol 1,4-bisphosphate in rat liver. Morris, A.J., Storey, D.J., Downes, C.P., Michell, R.H. Biochem. J. (1988) [Pubmed]
  7. Identification of rat liver glucose-3-phosphatase as an inositol monophosphatase inhibited by lithium. Canales, J., Buitrago, F., Faraldo, A., Avalos, M., Cameselle, J.C. Arch. Biochem. Biophys. (1997) [Pubmed]
  8. HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Hearps, A.C., Jans, D.A. Biochem. J. (2006) [Pubmed]
  9. Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment. Parthasarathy, L.K., Seelan, R.S., Wilson, M.A., Vadnal, R.E., Parthasarathy, R.N. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  10. Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1. Chen, X., McMahon, E.G., Gulve, E.A. Am. J. Physiol. (1998) [Pubmed]
  11. Chronodynamic evaluation of the stages of osseointegration in zirconium laminar implants. Guglielmotti, M.B., Guerrero, C., Cabrini, R.L. Acta odontológica latinoamericana : AOL. (1997) [Pubmed]
  12. Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. Kendall, D.A., Nahorski, S.R. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  13. Mass assay for inositol 1-phosphate in rat brain by high-performance liquid chromatography and pulsed amperometric detection. Barnaby, R.J. Anal. Biochem. (1991) [Pubmed]
  14. Intracerebroventricular antisense to inositol monophosphatase-1 reduces enzyme activity but does not affect Li-sensitive behavior. Shamir, A., Shaltiel, G., Agam, G. Prog. Neuropsychopharmacol. Biol. Psychiatry (2002) [Pubmed]
  15. Augmentation of lithium's behavioral effect by inositol uptake inhibitors. Einat, H., Kofman, O., Itkin, O., Lewitan, R.J., Belmaker, R.H. Journal of neural transmission (Vienna, Austria : 1996) (1998) [Pubmed]
  16. The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1. Forwood, J.K., Harley, V., Jans, D.A. J. Biol. Chem. (2001) [Pubmed]
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