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Gene Review

mce-1  -  Protein MCE-1

Caenorhabditis elegans

 
 
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High impact information on mce-1

  • RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules [1].
  • The C. elegans mce-1 deletion mutant demonstrates for the first time that a lesion at the epimerase step of methylmalonyl-CoA metabolism can functionally impair flux through the methylmalonyl-CoA mutase pathway and suggests that malfunction of MCEE may cause methylmalonic acidemia in humans [1].
  • Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: Evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism [1].
  • The sequence similarity to an MCE of known structure was high enough to permit a three-dimensional model to be built, suggesting conservation of ligand and metal binding sites [2].
 

Associations of mce-1 with chemical compounds

References

  1. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: Evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Chandler, R.J., Aswani, V., Tsai, M.S., Falk, M., Wehrli, N., Stabler, S., Allen, R., Sedensky, M., Kazazian, H.H., Venditti, C.P. Mol. Genet. Metab. (2006) [Pubmed]
  2. Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans. Kühnl, J., Bobik, T., Procter, J.B., Burmeister, C., Höppner, J., Wilde, I., Lüersen, K., Torda, A.E., Walter, R.D., Liebau, E. FEBS J. (2005) [Pubmed]
 
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