Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

unc-29 - Protein UNC-29

Caenorhabditis elegans

Fleming, J.T. et al., Kim, J. et al., Ballivet, M. et al., Richmond, J.E. et al.

Richmond, Jorgensen,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on unc-29

This response was eliminated in mutants lacking either the unc-38 or unc-29 genes, which encode alpha and non-alpha acetylcholine receptor subunits, respectively [1].
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits [2].
The corresponding genes were isolated and hybridized to YAC grids: Ce21 maps on chromosome V near the his-23 gene, and Ce13 on chromosome I very near or at unc-29 [3].
In addition, since expression of functional unc-29 in muscle cells restored levamisole sensitivity under some but not all conditions, both neuronal and muscle cell UNC-29 receptors are likely to contribute to the regulation of egg-laying behavior [4].

Biological context of unc-29

The mutant phenotypes reveal that unc-38 and unc-29 subunits are necessary for nAChR function, whereas the lev-1 subunit is not [2].

References

One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Richmond, J.E., Jorgensen, E.M. Nat. Neurosci. (1999) [Pubmed]
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. Fleming, J.T., Squire, M.D., Barnes, T.M., Tornoe, C., Matsuda, K., Ahnn, J., Fire, A., Sulston, J.E., Barnard, E.A., Sattelle, D.B., Lewis, J.A. J. Neurosci. (1997) [Pubmed]
Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. Ballivet, M., Alliod, C., Bertrand, S., Bertrand, D. J. Mol. Biol. (1996) [Pubmed]
Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. Kim, J., Poole, D.S., Waggoner, L.E., Kempf, A., Ramirez, D.S., Treschow, P.A., Schafer, W.R. Genetics (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg