Disease relevance of rbcS

• In Synechococcus cells, rbcL and rbcS encoding the large and small subunits, respectively, of ribulose-1,5-bisphosphate carboxylase/oxygenase are co-transcribed as a dicistronic mRNA, and the downstream rbcS mRNA possesses two possible initiation codons separated by three nucleotides [1].
• In most cyanobacteria, the gene rbcX is co-transcribed with the rbcL and rbcS genes that code for the large and small subunits of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) [2].
• The gene was stably introduced into tobacco plants under transcriptional control of the cauliflower mosaic virus 35S promoter, and the enzyme was targeted into plastids by the transit peptide of the pea RuBisCO small subunit [3].

Biological context of rbcS

• Two of these ORFs potentially encode the Synechococcus sp. strain WH7803 rbcL and rbcS genes [4].

Analytical, diagnostic and therapeutic context of rbcS

• Site-directed mutagenesis studies of the Anacystis rbcS has begun to provide information relative to RubisCO structure and function [5].

References