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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

spe-9  -  Protein SPE-9

Caenorhabditis elegans

 
 
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High impact information on spe-9

  • Therefore, disruption of spe-9 function affects either gamete recognition, adhesion, signaling, and/or fusion [1].
  • Fusion of CAV-1 bodies with the plasma membrane appears to be regulated by the advancing cell cycle, and not fertilization per se, because fusion can proceed in spe-9 fertilization mutants but is blocked by RNA interference-mediated knockdown of an anaphase-promoting complex component (EMB-27) [2].
  • Mutations in five genes (fer-7, spe-9, spe-11, spe-13 and spe-15) allow formation of normal looking motile spermatozoa that appear to be defective in either sperm-spermathecal or sperm-oocyte interactions [3].

References

  1. The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization. Singson, A., Mercer, K.B., L'Hernault, S.W. Cell (1998) [Pubmed]
  2. Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Sato, K., Sato, M., Audhya, A., Oegema, K., Schweinsberg, P., Grant, B.D. Mol. Biol. Cell (2006) [Pubmed]
  3. Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. L'Hernault, S.W., Shakes, D.C., Ward, S. Genetics (1988) [Pubmed]
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