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Gene Review

spe-9  -  Protein SPE-9

Caenorhabditis elegans

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High impact information on spe-9

  • Therefore, disruption of spe-9 function affects either gamete recognition, adhesion, signaling, and/or fusion [1].
  • Fusion of CAV-1 bodies with the plasma membrane appears to be regulated by the advancing cell cycle, and not fertilization per se, because fusion can proceed in spe-9 fertilization mutants but is blocked by RNA interference-mediated knockdown of an anaphase-promoting complex component (EMB-27) [2].
  • Mutations in five genes (fer-7, spe-9, spe-11, spe-13 and spe-15) allow formation of normal looking motile spermatozoa that appear to be defective in either sperm-spermathecal or sperm-oocyte interactions [3].


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