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Gene Review:

pfn-1 - Protein PFN-1

Caenorhabditis elegans

Polet, D. et al., Severson, A.F. et al.

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High impact information on Profilins

A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans [1].
Profilins are actin binding proteins, which also interact with polyphosphoinositides and proline-rich ligands [2].
On the basis of the genome sequence, three diverse profilin homologues (PFN) are predicted to exist in Caenorhabditis elegans [2].

References

A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans. Severson, A.F., Baillie, D.L., Bowerman, B. Curr. Biol. (2002) [Pubmed]
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Polet, D., Lambrechts, A., Ono, K., Mah, A., Peelman, F., Vandekerckhove, J., Baillie, D.L., Ampe, C., Ono, S. Cell Motil. Cytoskeleton (2006) [Pubmed]

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