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Gene Review

Wnt4  -  wingless-type MMTV integration site family...

Rattus norvegicus

Synonyms: Protein Wnt-4, Wnt-4
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Disease relevance of Wnt4


High impact information on Wnt4


Biological context of Wnt4


Anatomical context of Wnt4

  • This study suggests that Wnt-4 and -11 are likely to be important mediators of the transformation of mesenchyme to epithelium in the kidney [2].

Other interactions of Wnt4

  • Although the time courses of Wnt4, Wnt5a, and Wnt7a mRNA status varied until 12 h after EE administration, all of them were simultaneously downregulated at 24 and 48 h [4].
  • Compared with expression in wild type cells, both PC12/flat and PC12/Wnt1 cells lost most or all expression of Wnt3a and Wnt4 and gained expression of Wnt7b [6].
  • Wnt-4 (a Wingless-like morphogenic gene involved in MG development), ERbeta and ERbeta2 mRNA were evaluated by RT-PCR analysis [7].


  1. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada, Y., Tanaka, H., Okado, T., Shimamura, H., Inoshita, S., Kuwahara, M., Sasaki, S. J. Am. Soc. Nephrol. (2003) [Pubmed]
  2. Expression of the Wnt gene family during late nephrogenesis and complete ureteral obstruction. Nguyen, H.T., Thomson, A.A., Kogan, B.A., Baskin, L.S., Cunha, G.R. Lab. Invest. (1999) [Pubmed]
  3. Establishment of renal stem/progenitor-like cell line from S3 segment of proximal tubules in adult rat kidney. Kitamura, S., Yamasaki, Y., Makino, H. Kidney Int. (2005) [Pubmed]
  4. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama, S., Ashizawa, K., Fukuhara, T., Hiroyasu, M., Tsuzuki, Y., Tatemoto, H., Nakada, T., Nagai, K. Toxicol. Sci. (2006) [Pubmed]
  5. Perturbation of RET signaling in the embryonic kidney. Ehrenfels, C.W., Carmillo, P.J., Orozco, O., Cate, R.L., Sanicola, M. Dev. Genet. (1999) [Pubmed]
  6. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Erdreich-Epstein, A., Shackleford, G.M. Growth Factors (1998) [Pubmed]
  7. Association of increased estrogen receptor beta2 expression with parity-induced alterations in the rat mammary gland. Kass, L., Durando, M., Ramos, J.G., Varayoud, J., Powell, C.E., Luque, E.H., Muñoz-de-Toro, M. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
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