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Gene Review

WNT4  -  wingless-type MMTV integration site family...

Gallus gallus

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High impact information on WNT4

  • This phenotype can be enhanced by removal of an additional Wnt gene, Wnt4, suggesting that Wnts are playing a crucial role in directing bi-potential chondro-synovioprogenitors to become synovial connective tissue, by actively suppressing their chondrogenic potential [1].
  • In situ hybridization revealed that genes for three Frizzled receptors, c-Fz1, c-Fz7, and c-Fz10, are expressed in and adjacent to sensory primordia, while Wnt4 is expressed in adjacent, nonsensory regions of the cochlear duct [2].


  1. Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Später, D., Hill, T.P., O'sullivan, R.J., Gruber, M., Conner, D.A., Hartmann, C. Development (2006) [Pubmed]
  2. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Stevens, C.B., Davies, A.L., Battista, S., Lewis, J.H., Fekete, D.M. Dev. Biol. (2003) [Pubmed]
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