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Gene Review

wnt4a  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: Protein Wnt-4a, SO:0000704, wnt-4, wnt4, zgc:136737
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High impact information on wnt4a

  • Comparison of the phenotypes arising from misexpression of wnt4 and Xwnt-5A in both organisms suggests close parallels in the response to these Wnts [1].
  • During somitogenesis, wnt4 appears in the floor plate, and this expression is absent in cyclops mutants, which lack floor plate. wnt4 is also expressed in the developing pronephros and gill slit [1].
  • The wnt4 transcript is first detected early in somitogenesis, in the dorsocaudal region of the forebrain, and then appears in the dorsal and lateral regions of the caudal hindbrain and neural keel [1].


  1. Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo. Ungar, A.R., Kelly, G.M., Moon, R.T. Mech. Dev. (1995) [Pubmed]
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