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Gene Review:

Mknk1 - MAP kinase-interacting serine/threonine...

Mus musculus

Synonyms: 2410048M24Rik, MAP kinase signal-integrating kinase 1, MAP kinase-interacting serine/threonine-protein kinase 1, MAPK signal-integrating kinase 1, Mnk1

Banko, J.L. et al., Ueda, T. et al., Waskiewicz, A.J. et al.

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High impact information on Mknk1

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development [1].
We identified activating phosphorylation sites in Mnk1 and developed dominant-negative and activated mutants [2].

Associations of Mknk1 with chemical compounds

The NMDA-induced activation of Mnk1 and increased phosphorylation of eIF4E were dependent on PKA and ERK, but not PKC, and were present in synaptoneurosome preparations [3].

References

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Ueda, T., Watanabe-Fukunaga, R., Fukuyama, H., Nagata, S., Fukunaga, R. Mol. Cell. Biol. (2004) [Pubmed]
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Waskiewicz, A.J., Johnson, J.C., Penn, B., Mahalingam, M., Kimball, S.R., Cooper, J.A. Mol. Cell. Biol. (1999) [Pubmed]
NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1. Banko, J.L., Hou, L., Klann, E. J. Neurochem. (2004) [Pubmed]

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