High impact information on Lk6

• Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development [1].
• This work demonstrates that Lk6 exerts a tight control on eIF4E phosphorylation and is necessary for normal growth and development [1].
• These findings suggest that LK6 may play a role in regulating microtubule function [2].
• At least some of the LK6 protein is located in centrosomes at all stages of the cell cycle in fly embryos [2].
• Here we report the cloning of one such cDNA that encodes a novel serine/threonine protein kinase called LK6 [2].

Biological context of Lk6

• Constitutive overexpression of LK6 is deleterious to flies and causes defects in microtubule organisation in both eggs and early embryos, whereas constitutive overexpression of a mutant form containing a point mutation that severely impairs the kinase activity is without effect [2].

Other interactions of Lk6

• One is Lk6, which encodes a protein kinase predicted to regulate the rate-limiting initiation factor eIF4E [3].
• In this screen, we recovered three known genes, Lk6, misshapen, and Akap200 [4].

References