Gene Review:
Eif4e - eukaryotic translation initiation factor 4E
Mus musculus
Synonyms:
EG668879, Eif4e-ps, Eukaryotic translation initiation factor 4E, If4e, eIF-4E, ...
- Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Williamson, D.L., Kimball, S.R., Jefferson, L.S. Am. J. Physiol. Endocrinol. Metab. (2005)
- Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. Tenenbaum, S.A., Carson, C.C., Lager, P.J., Keene, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000)
- c-Jun NH2-Terminal Kinase 2{alpha}2 Promotes the Tumorigenicity of Human Glioblastoma Cells. Cui, J., Han, S.Y., Wang, C., Su, W., Harshyne, L., Holgado-Madruga, M., Wong, A.J. Cancer Res. (2006)
- The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication. Gierman, T.M., Frederickson, R.M., Sonenberg, N., Pickup, D.J. Virology (1992)
- Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Buechler, R.D., Peffley, D.M. Mol. Carcinog. (2004)
- The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Ruggero, D., Montanaro, L., Ma, L., Xu, W., Londei, P., Cordon-Cardo, C., Pandolfi, P.P. Nat. Med. (2004)
- Ras mediates translation initiation factor 4E-induced malignant transformation. Lazaris-Karatzas, A., Smith, M.R., Frederickson, R.M., Jaramillo, M.L., Liu, Y.L., Kung, H.F., Sonenberg, N. Genes Dev. (1992)
- Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. Beretta, L., Gingras, A.C., Svitkin, Y.V., Hall, M.N., Sonenberg, N. EMBO J. (1996)
- mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. Koromilas, A.E., Lazaris-Karatzas, A., Sonenberg, N. EMBO J. (1992)
- Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains. Rodriguez, L.A., Plomin, R., Blizard, D.A., Jones, B.C., McClearn, G.E. Alcohol. Clin. Exp. Res. (1995)
- Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Ueda, T., Watanabe-Fukunaga, R., Fukuyama, H., Nagata, S., Fukunaga, R. Mol. Cell. Biol. (2004)
- Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Khaleghpour, K., Pyronnet, S., Gingras, A.C., Sonenberg, N. Mol. Cell. Biol. (1999)
- Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. Williamson, D.L., Kubica, N., Kimball, S.R., Jefferson, L.S. J. Physiol. (Lond.) (2006)
- Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids. Shen, W.H., Boyle, D.W., Wisniowski, P., Bade, A., Liechty, E.A. J. Endocrinol. (2005)
- Translation initiation factor 4E inhibits differentiation of erythroid progenitors. Blázquez-Domingo, M., Grech, G., von Lindern, M. Mol. Cell. Biol. (2005)
- Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. Morley, S.J., McKendrick, L. J. Biol. Chem. (1997)
- Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. Niedzwiecka, A., Marcotrigiano, J., Stepinski, J., Jankowska-Anyszka, M., Wyslouch-Cieszynska, A., Dadlez, M., Gingras, A.C., Mak, P., Darzynkiewicz, E., Sonenberg, N., Burley, S.K., Stolarski, R. J. Mol. Biol. (2002)
- Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Goggin, M.M., Nelsen, C.J., Kimball, S.R., Jefferson, L.S., Morley, S.J., Albrecht, J.H. Hepatology (2004)
- The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Rousseau, D., Gingras, A.C., Pause, A., Sonenberg, N. Oncogene (1996)
- Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. Lin, T.A., Kong, X., Saltiel, A.R., Blackshear, P.J., Lawrence, J.C. J. Biol. Chem. (1995)
- Cell cycle progression and proliferation despite 4BP-1 dephosphorylation. Marx, S.O., Marks, A.R. Mol. Cell. Biol. (1999)
- Initiation of mRNA translation in oncogenesis: the role of eIF4E. Montanaro, L., Pandolfi, P.P. Cell Cycle (2004)
- Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. Rosenwald, I.B., Kaspar, R., Rousseau, D., Gehrke, L., Leboulch, P., Chen, J.J., Schmidt, E.V., Sonenberg, N., London, I.M. J. Biol. Chem. (1995)
- Erythropoietin stimulates phosphorylation of eIF-4E and identification of a 37-kD phosphoprotein that binds mRNA caps in erythroblasts. Bu, X., Bondurant, M.C., Hagedorn, C.H. Exp. Hematol. (1996)
- High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. Mochizuki, K., Oguro, A., Ohtsu, T., Sonenberg, N., Nakamura, Y. RNA (2005)
- Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. Rosenwald, I.B., Rhoads, D.B., Callanan, L.D., Isselbacher, K.J., Schmidt, E.V. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Positive heat capacity change upon specific binding of translation initiation factor eIF4E to mRNA 5' cap. Niedzwiecka, A., Stepinski, J., Darzynkiewicz, E., Sonenberg, N., Stolarski, R. Biochemistry (2002)
- Cap-binding activity of an eIF4E homolog from Leishmania. Yoffe, Y., Zuberek, J., Lewdorowicz, M., Zeira, Z., Keasar, C., Orr-Dahan, I., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., Shapira, M. RNA (2004)
- Overexpressing eukaryotic translation initiation factor 4E stimulates bovine mammary epithelial cell proliferation. Long, E., Lazaris-Karatzas, A., Karatzas, C., Zhao, X. Int. J. Biochem. Cell Biol. (2001)