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Gene Review

Mmp16  -  matrix metallopeptidase 16

Mus musculus

Synonyms: MMP-16, MT-MMP 3, MT3-MMP, MT3MMP, MTMMP3, ...
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High impact information on Mmp16

  • MT3-MMP requires TIMP-2 to accomplish full pro-MMP-2 activation and this process is enhanced in marimastatpretreated cells, consistent with regulation of active enzyme turnover by synthetic MMP inhibitors [1].
  • TIMP-3 also enhances the activation of pro-MMP-2 by MT3-MMP but not by MT1-MMP [1].
  • Here we investigated the processing, catalytic activity, and TIMP inhibition of MT3-MMP (MMP-16) [1].
  • Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs [2].
  • MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland [2].

Anatomical context of Mmp16

  • MT1-MMP was localized in the epithelial tissue of the cornea, whereas MT2-MMP and MT3-MMP were mainly found in the interface between the epithelium and substantia propria [3].

Other interactions of Mmp16

  • These results demonstrate that TIMP-3 is a major regulator of MT3-MMP activity and further underscores the unique interactions of TIMPs with MT-MMPs in the control of pericellular proteolysis [1].


  1. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation. Zhao, H., Bernardo, M.M., Osenkowski, P., Sohail, A., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P.D., DeClerck, Y.A., Fridman, R. J. Biol. Chem. (2004) [Pubmed]
  2. Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland. Szabova, L., Yamada, S.S., Birkedal-Hansen, H., Holmbeck, K. J. Cell. Physiol. (2005) [Pubmed]
  3. Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa. Dong, Z., Ghabrial, M., Katar, M., Fridman, R., Berk, R.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
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