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Gene Review:

Mmp15 - matrix metallopeptidase 15

Mus musculus

Synonyms: AI503551, MMP-15, MT-MMP 2, MT2-MMP, MT2MMP, ...

Szabova, L. et al., Tanaka, M. et al., Bassi, D.E. et al., Toft-Hansen, H. et al., Dong, Z. et al.

Toft-Hansen, Nuttall, Edwards, Owens,

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High impact information on Mmp15

Transgenic keratinocytes showed increased processing of MT1-MMP and MT2-MMP resulting in collagenase IV activation and collagen type IV degradation [1].
Strikingly, the expression of MMP-15 by microglia was significantly down-regulated in EAE, which was confirmed by immunostaining [2].
Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs [3].
In contrast, MT2-MMP was found exclusively in the mammary epithelium [3].
CONCLUSIONS: MT1-MMP was detected and expressed to a greater extent in naive mice than MT2-MMP and MT3-MMP [4].

Biological context of Mmp15

Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product [5].

Anatomical context of Mmp15

Like MT1- and MT3-MMPs, mouse MT2-MMP caused activation of progelatinase A upon co-transfection into COS-1 cells [5].

References

PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Bassi, D.E., Lopez De Cicco, R., Cenna, J., Litwin, S., Cukierman, E., Klein-Szanto, A.J. Cancer Res. (2005) [Pubmed]
Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis. Toft-Hansen, H., Nuttall, R.K., Edwards, D.R., Owens, T. J. Immunol. (2004) [Pubmed]
Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland. Szabova, L., Yamada, S.S., Birkedal-Hansen, H., Holmbeck, K. J. Cell. Physiol. (2005) [Pubmed]
Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa. Dong, Z., Ghabrial, M., Katar, M., Fridman, R., Berk, R.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product. Tanaka, M., Sato, H., Takino, T., Iwata, K., Inoue, M., Seiki, M. FEBS Lett. (1997) [Pubmed]

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