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Gene Review

Mmp16  -  matrix metallopeptidase 16

Rattus norvegicus

Synonyms: MMP-16, MT-MMP 3, MT3-MMP, MT3MMP, MTMMP3, ...
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Disease relevance of Mmp16

  • Semiquantitative RT-PCR analysis revealed that among the three members of the MT-MMP family, mRNA expression of MT2-MMP remained unchanged and that of MT3-MMP was not observed in glomeruli during the development of nephritis [1].

High impact information on Mmp16

  • When the MT3-MMP cDNA was expressed in COS-7 cells, endogenous progelatinase A was processed to the mature form [2].
  • The present study suggests that multiple forms of MMPs including MT3-MMP are involved in the matrix remodeling of blood vessels [2].
  • Both MT3-MMP-del and MT3-MMP hydrolyzed gelatin and casein, indicating their broad substrate specificity [2].
  • A rat MT3-MMP cDNA encoding 607 amino acids and a cDNA for its transmembrane domainless variant MT3-MMP-del were cloned from a rat SMC cDNA library; a human MT3-MMP cDNA was cloned from a fetal brain cDNA library [2].
  • In contrast, there were no remarkable changes in the gene expression of MT2-MMP between normal and diseased tissue, and that of MT3-MMP was not detected in isolated glomeruli by reverse transcription-PCR analysis [3].

Associations of Mmp16 with chemical compounds

  • Effect of Losartan on the mRNA Expressions of MT3-MMP and TIMP-2 in Diabetic Kidneys [4].

Other interactions of Mmp16

  • In contrast, in MT3-MMP overexpressing cells, MMP-2 activation was partial [5].
  • Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms [6].

Analytical, diagnostic and therapeutic context of Mmp16

  • After a period of 18 weeks, the kidneys were extracted from all rats in order to measure the mRNA expressions of MT3-MMP, TIMP-2 and transforming growth factor-beta1 (TGF-beta1) by RT-PCR [4].


  1. Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. Hayashi, K., Horikoshi, S., Osada, S., Shofuda, K., Shirato, I., Tomino, Y. J. Pathol. (2000) [Pubmed]
  2. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. Shofuda, K., Yasumitsu, H., Nishihashi, A., Miki, K., Miyazaki, K. J. Biol. Chem. (1997) [Pubmed]
  3. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. Hayashi, K., Osada, S., Shofuda, K., Horikoshi, S., Shirato, I., Tomino, Y. J. Am. Soc. Nephrol. (1998) [Pubmed]
  4. Effect of Losartan on the mRNA Expressions of MT3-MMP and TIMP-2 in Diabetic Kidneys. Ding, H.L., Xu, M.T., Guo, Y., Chen, L., Zhang, S.L., Li, F., Fu, Z.Z. The review of diabetic studies : RDS (2005) [Pubmed]
  5. Control of smooth muscle cell function by membrane-type matrix metalloproteinases. Shofuda, K.I., Hasenstab, D., Shofuda, T., Kenagy, R.D., Clowes, A.W. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  6. Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration. van Bilsen, J.H., Wagenaar-Hilbers, J.P., van der Cammen, M.J., van Dijk, M.E., van Eden, W., Wauben, M.H. Arthritis Res. (2002) [Pubmed]
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