Disease relevance of Mmp16

• Semiquantitative RT-PCR analysis revealed that among the three members of the MT-MMP family, mRNA expression of MT2-MMP remained unchanged and that of MT3-MMP was not observed in glomeruli during the development of nephritis [1].

High impact information on Mmp16

• When the MT3-MMP cDNA was expressed in COS-7 cells, endogenous progelatinase A was processed to the mature form [2].
• The present study suggests that multiple forms of MMPs including MT3-MMP are involved in the matrix remodeling of blood vessels [2].
• Both MT3-MMP-del and MT3-MMP hydrolyzed gelatin and casein, indicating their broad substrate specificity [2].
• A rat MT3-MMP cDNA encoding 607 amino acids and a cDNA for its transmembrane domainless variant MT3-MMP-del were cloned from a rat SMC cDNA library; a human MT3-MMP cDNA was cloned from a fetal brain cDNA library [2].
• In contrast, there were no remarkable changes in the gene expression of MT2-MMP between normal and diseased tissue, and that of MT3-MMP was not detected in isolated glomeruli by reverse transcription-PCR analysis [3].

Associations of Mmp16 with chemical compounds

• Effect of Losartan on the mRNA Expressions of MT3-MMP and TIMP-2 in Diabetic Kidneys [4].

Other interactions of Mmp16

• In contrast, in MT3-MMP overexpressing cells, MMP-2 activation was partial [5].
• Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms [6].

Analytical, diagnostic and therapeutic context of Mmp16

• After a period of 18 weeks, the kidneys were extracted from all rats in order to measure the mRNA expressions of MT3-MMP, TIMP-2 and transforming growth factor-beta1 (TGF-beta1) by RT-PCR [4].

References